-
Article
Continuous cocaine induces persisting alterations in dopamine overflow in caudate following perfusion with a D1 agonist
The present study examined whether exposure to 5 days of continuous cocaine in rats would produce any persisting alterations of the decrease in striatal dopamine (DA) overflow produced by local infusion of a D...
-
Article
Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats
Rats were administered haloperidol, clozapine, raclopride, or no drug for 28 days or 8 months. Following a 3 week withdrawal period, in vitro autoradiography was utilized to examine receptor binding for dopami...
-
Article
Tremorous mouth movements in rats administered chronic neuroleptics
Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the uppe...
-
Article
The regional distribution of d-amphetamine and local glucose utilization in rat brain during continuous amphetamine administration
The distribution of radioactivity following administration of either [3H]d-amphetamine or [3H]2-deoxy-d-glucose was examined by scintillation counting of 22 microdissected brain regions from rats pretreated with ...
-
Article
Stages of recovery from central norepinephrine lesions in enriched and impoverished environments: A behavioral and biochemical study
Adult rats were injected intraventricularly with 6-OHDA and allowed to recover for varying time periods in either an enriched colony environment or in isolation cages. When tested behaviorally in a novel envir...