36 Result(s)
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Biochemistry, general
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Article
Biochemical Characterization of a Marine Pseudoalteromonas citrea-Derived Fatty Acyl-AMP Ligase That Exhibits N-Acyl Amino Acid Synthetic Activity
Activation of fatty acids as acyl-adenylates by fatty acid-AMP ligase (FAAL) is a well-established process contributing to the formation of various functional natural products. Enzymatic characterization of FA...
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Article
Open AccessThe roles of Th cells in myocardial infarction
Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart, leading to tissue damage. A significant aspect of this condit...
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Article
Protective Effect of Ginkgo biloba (Ginkgoaceae Family) Leaf Extracts on Female Drosophila melanogaster Suffering from Ultraviolet Irradiation through Activating the Keap1-Nrf2 Signaling Pathway
Ginkgo biloba leaf extracts (GBLE) possess strong physiological activities, such as antioxidant and anti-inflammatory effects. In the experiment, the mitigating effects of GBLE on ultraviolet (UV) radiation-induc...
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Article
EGR1-Driven METTL3 Activation Curtails VIM-Mediated Neuron Injury in Epilepsy
Uncovering mechanisms underlying epileptogenesis aids in preventing further epilepsy progression and to lessen seizure severity and frequency. The purpose of this study is to explore the antiepileptogenic and ...
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Article
Development of Child-Friendly Lisdexamfetamine Chewable Tablets Using Ion Exchange Resin as a Taste-Masking Carrier Based on the Concept of Quality by Design (QbD)
Taste masking is critical to improving the compliance of pediatric oral dosage forms. However, it is challenging for extremely bitter lisdexamfetamine dimesylate (LDX) with a long half-life and given in large ...
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Article
Retraction Note: Resibufogenin suppresses tumor growth and Warburg effect through regulating miR-143-3p/HK2 axis in breast cancer
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Article
Phloroglucinol derivatives as anti-tumor agents: synthesis, biological activity evaluation and molecular docking studies
Phloroglucinol compounds isolated from Dryopteris fragrans (L.) Schott showed a variety of biological activities, such as anticancer and anti-inflammatory. In this study, we have made a number of modifications ar...
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Article
A colorimetric sensing platform for azodicarbonamide detection in flour based on MnO2 nanosheets oxidative system
Azodicarbonamide (ADA), as a dough conditioner food additive in flour, can be turned into toxic biurea and semicarbazide after high temperature processing. Hence, the using of ADA in food material should be st...
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Article
Correction to: Effect of Packaging Materials and the Leached Iron on the Stability of Butorphanol Tartrate Injection
Correction to: In this article, Haoxiang Wu should have been denoted as a corresponding author.
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Article
Effect of Packaging Materials and the Leached Iron on the Stability of Butorphanol Tartrate Injection
The aim of this study was to investigate the effect of various parameters on the stability of butorphanol tartrate injection and to screen the optimal packaging material. The effect of the headspace oxygen lev...
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Article
Open AccessUtidelone inhibits growth of colorectal cancer cells through ROS/JNK signaling pathway
Utidelone (UTD1), a novel microtubule stabilizing agent, is an epothilone B analogue which was produced by genetic engineering. UTD1 has exhibited broad antitumor activity in multiple solid tumors. However, it...
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Article
RETRACTED ARTICLE: Resibufogenin suppresses tumor growth and Warburg effect through regulating miR-143-3p/HK2 axis in breast cancer
Increasing evidence confirmed that the Warburg effect plays an important role involved in the progression of malignant tumors. Resibufogenin (RES) has been proved to have a therapeutic effect in multiple malig...
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Article
A Fluorescent Sensor for Cu2+ Ion with High Selectivity and Sensitivity Based on ICT and PET
A novel fluorescent sensor (L) based on 1,8-naphthalic anhydride has been developed which can selectively detect Cu2+ in CH3CN medium over other metal ions at 408 nm in the fluorescence spectra. When Cu2+ was add...
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Article
Development of an Efficient and Cost-Effective Enzymatic Process for Production of (R)-[3,5-bis(trifluoromethyl)phenyl] Ethanol Using Carbonyl Reductase Derived from Leifsonia sp. S749
(R)-[3,5-bis(trifluoromethyl) phenyl] ethanol [(R)-3,5-BTPE] is a crucial chiral intermediate for the synthesis of the NK-1 receptor antagonists aprepitant, rolapitant and fosaprepitant. The carbonyl reductase...
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Article
Broadband Terahertz Absorption in Graphene-Embedded Photonic Crystals
The absorption in graphene is rather low at terahertz frequencies. Here, we present a graphene-embedded photonic crystal structure to realize broadband terahertz absorption in graphene. The approach provides a...
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Article
Overexpression of a Chitinase Gene from Trichoderma asperellum Increases Disease Resistance in Transgenic Soybean
In the present study, a chi gene from Trichoderma asperellum, designated Tachi, was cloned and functionally characterized in soybean. Firstly, the effects of sodium thiosulfate on soybean Agrobacterium-mediated g...
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Article
A purple acid phosphatase plays a role in nodule formation and nitrogen fixation in Astragalus sinicus
The AsPPD1 gene from Astragalus sinicus encodes a purple acid phosphatase. To address the functions of AsPPD1 in legume-rhizobium symbiosis, its expression patterns, enzyme activity, subcellular localization, and...
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Article
Salsolinol Damaged Neuroblastoma SH-SY5Y Cells Induce Proliferation of Human Monocyte THP-1 Cells Through the mTOR Pathway in a Co-culture System
Despite extensive efforts to study the inflammatory process in the central nervous system of Parkinson’s disease (PD) patients, little is known about the role of peripheral blood mononuclear cells (PBMCs) in ...
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Article
Transcriptome profiling of Vitis amurensis, an extremely cold-tolerant Chinese wild Vitis species, reveals candidate genes and events that potentially connected to cold stress
Vitis amurensis Rupr. is an exceptional wild-growing Vitis (grape) species that can safely survive a wide range of cold conditions, but the underlying cold-adaptive mechanism associated with gene...
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Article
A Novel Dextran Dextrinase from Gluconobacter oxydans DSM-2003: Purification and Properties
Dextran has already been widely applied in food, pharmaceutical, and chemical industries. In this study, a novel intracellular dextran dextrinase (DDase, EC 2.4.1.2) from Gluconobacter oxydans DSM-2003 exhibiting...
