-
Article
Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer
Colorectal cancer (CRC), a prevalent malignancy worldwide, has prompted extensive research into anticancer drugs. Traditional Chinese medicinal materials offer promising avenues for cancer management due to th...
-
Article
Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women
In East Asia, the incidence of breast cancer has been increasing rapidly, particularly among premenopausal women. An elevated ratio of estrogen-DNA adducts was linked to a higher risk of breast cancer. The pre...
-
Article
Open AccessDevelo** an entrustable professional activity for providing health education and consultation in occupational therapy and examining its validity
Entrustable Professional Activities (EPA)-based assessment is easily and intuitively used in evaluating the learning outcomes of competency-based medical education (CBME). This study aimed to develop an EPA fo...
-
Article
Open AccessDevelopment of a risk prediction model for radiation dermatitis following proton radiotherapy in head and neck cancer using ensemble machine learning
This study aims to develop an ensemble machine learning-based (EML-based) risk prediction model for radiation dermatitis (RD) in patients with head and neck cancer undergoing proton radiotherapy, with the goal...
-
Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
-
Article
Open AccessReal-World Efficacy and Safety of Universal 8-Week Glecaprevir/Pibrentasvir for Treatment-Naïve Patients from a Nationwide HCV Registry in Taiwan
Eight-week glecaprevir/pibrentasvir (GLE/PIB) is indicated for treatment-naïve (TN) patients with chronic hepatitis C (CHC), with or without compensated cirrhosis. Given that the Taiwanese government is commit...
-
Article
Molecular phylogeny of Podoscypha (Basidiomycota, Podoscyphaceae) with descriptions of four new species, inferred from nuclear rDNA sequences
Seven species of Podoscypha (including four new species) and two species of Cymatoderma collected from the Guangxi Zhuang Autonomous Region in Southwest China were studied. Phylogenetic analyses of both the ITS a...
-
Article
Open AccessResponse of ion velocities of daytime ionospheric wavenumber-4 to solar activity observed by ROCSAT-1 and DEMETER
The electron/ion density/temperature and ion velocities observed by the ROCSAT-1 and DEMETER satellites are used to examine the daytime wavenumber-4 (WN4) feature in the equatorial/low latitude ionosphere duri...
-
Article
ABCC4 suppresses glioblastoma progression and recurrence by restraining cGMP-PKG signalling
Cyclic nucleotides are critical mediators of cellular signalling in glioblastoma. However, the clinical relevance and mechanisms of regulating cyclic nucleotides in glioblastoma progression and recurrence have...
-
Article
Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients
Metrnl is a secreted protein involved in neurite outgrowth, insulin sensitivity, immunoinflammatory responses, blood lipids and endothelial protection. In this study, we investigated the role of Metrnl in isch...
-
Article
Open AccessDeep learning assists in acute leukemia detection and cell classification via flow cytometry using the acute leukemia orientation tube
This study aimed to evaluate the sensitivity of AI in screening acute leukemia and its capability to classify either physiological or pathological cells. Utilizing an acute leukemia orientation tube (ALOT), on...
-
Article
Open AccessAn algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan
Both European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA) guidelines recommend simplified ...
-
Article
Comparison of Short-Term Outcomes After Robotic Versus Laparoscopic Radical Gastrectomy for Advanced Gastric Cancer in Elderly Individuals: A Propensity Score-Matching Study
Robotic gastrectomy (RG) has been widely used to treat gastric cancer. However, whether the short-term outcomes of robotic gastrectomy are superior to those of laparoscopic gastrectomy (LG) for elderly patient...
-
Article
Open AccessTrajectories of neutrophil-to-lymphocyte ratios during neoadjuvant chemotherapy correlate with short- and long-term outcomes in gastric cancer: a group-based trajectory analysis
Systemic inflammatory factors can predict the survival prognosis of gastric cancer (GC) patients after neoadjuvant chemotherapy (NACT). However, whether longitudinal changes in systemic inflammatory factors ar...
-
Article
Open AccessWheat flour-derived amyloid fibrils for efficient removal of organic dyes from contaminated water
Amyloid fibrils derived from different proteins have been proved as a promising material for adsorption of various pollutants from wastewater, which showed advantages of low cost and eco-friendliness. However,...
-
Article
Open AccessEpidemiology and outcomes of multidrug-resistant bacterial infection in non-cystic fibrosis bronchiectasis
Multidrug-resistant (MDR) bacteria impose a considerable health-care burden and are associated with bronchiectasis exacerbation. This study investigated the clinical outcomes of adult patients with bronchiecta...
-
Article
Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
-
Article
Open AccessSpatial analyses on pre-earthquake ionospheric anomalies and magnetic storms observed by China seismo-electromagnetic satellite in August 2018
The China Seismo-Electromagnetic Satellite (CSES), with a sun-synchronous orbit at 507 km altitude, was launched on 2 February 2018 to investigate pre-earthquake ionospheric anomalies (PEIAs) and ionospheric s...
-
Article
Open AccessHeart failure classification using deep learning to extract spatiotemporal features from ECG
Heart failure is a syndrome with complex clinical manifestations. Due to increasing population aging, heart failure has become a major medical problem worldwide. In this study, we used the MIMIC-III public dat...
-
Article
Ferroelectric transistors based on shear-transformation-mediated rhombohedral-stacked molybdenum disulfide
To develop low-power, non-volatile computing-in-memory device using ferroelectric transistor technologies, ferroelectric channel materials with scaled thicknesses are required. Two-dimensional semiconductors, ...
