2,324 Result(s)
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Fu** Qian
Biomedicine, general
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Article
Open AccessGPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
Acetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116) is an important homeostatic maintenance molecule in the body, but litt...
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Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment
Cancer immunotherapy has rapidly become the fourth mainstream treatment alternative after surgery, radiotherapy, and chemotherapy, with some promising results. It aims to kill tumor cells by mobilizing or stim...
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Article
Open AccessThe ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis
Renal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with a poor prognosis and high mortality. Angiopoietin-like 4 (ANGPTL4) is known to be associated with fibrosis in vario...
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Article
Open AccessTargeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis
Nod-like receptor family pyrin-containing protein 3 (NLRP3) inflammasome plays a pathologic role in metabolic dysfunction-associated steatohepatitis (MASH), but the molecular mechanism regulating the NLRP3 inf...
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Article
Boring holes in Au nanoplates by active surface etching
In contrast to the conventional etching that makes nanoparticles rounder and our previous sharpening etching mode that causes serrated edges, here, we developed a new boring etching mode that targets the faces...
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Metronomic chemotherapy plus anti-PD-1 in metastatic breast cancer: a Bayesian adaptive randomized phase 2 trial
It remains unclear whether metronomic chemotherapy is superior to conventional chemotherapy when combined with immune checkpoint blockade. Here we performed a phase 2 clinical trial of metronomic chemotherapy ...
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Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge
Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon antigen recall. How this decision is programmed is not understood. We found that the relative strength between two ant...
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Open AccessEAF2 Downregulation Recruits Tumor-associated Macrophages in Prostate Cancer through Upregulation of MIF
The role of tumor inflammatory microenvironment in the advancement of cancer, particularly prostate cancer, is widely acknowledged. ELL-associated factor 2 (EAF2), a tumor suppressor that has been identified i...
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Open AccessCorrection: Deep Immunophenoty** of Human Whole Blood by Standardized Multi-parametric Flow Cytometry Analyses
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Article
Correction to: Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
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Article
Open AccessHypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma
Urothelial carcinoma (UC) is the second most common urological malignancy. Despite numerous molecular markers have been evaluated during the past decades, no urothelial markers for diagnosis and recurrence mon...
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Open AccessErratum to: Improving the hydrostability of zeolitic imidazolate framework coatings using a facile silk fibroin protein modification method
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Open AccessThe relationship between the structural changes in the cervical spinal cord and sensorimotor function of children with thoracolumbar spinal cord injury (TLSCI)
Cross-sectional study.
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Article
Li2ZnTi3O8 as the host-separator modifier with efficient polysulfides trap** and fast Li+ diffusion for lithium-sulfur batteries
The diffusion and loss of lithium polysulfides (LiPSs) in lithium-sulfur batteries (LSBs) reduce the sulfur utilization rate and the catalytic conversion efficiency of sulfur species, resulting in early batter...
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Article
Perpendicularly assembled oriented electrospinning nanofibers based piezoresistive pressure sensor with wide measurement range
With the rapid development of wearable electronics, flexible pressure sensors have attracted wide attention in human-computer interaction and intelligent machines. However, it is a challenge to achieve a senso...
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Article
Revealing the role of electrode potential micro-environments in single Mn atoms for carbon dioxide and oxygen electrolysis
Elucidation the relationship between electrode potentials and heterogeneous electrocatalytic reactions has attracted widespread attention. Herein we construct the well-defined Mn single-atom (MnSA) catalyst wi...
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Article
Structure-regulated fluorine-containing additives to improve the performance of perovskite solar cells
Perovskite solar cells (PSCs) have seen remarkable progress in recent years, largely attributed to various additives that enhance both efficiency and stability. Among these, fluorine-containing additives have ...
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Article
M2-type macrophage membrane-mediated delivery of Carvedilol nanocomplex for acute liver failure treatment and remodeling inflammatory microenvironment
Interactions of hepatic macrophages with local inflammatory microenvironment is the key factor promoting the development of acute liver failure (ALF). Hence, reprogramming pro-inflammatory M1 into anti-inflamm...
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Article
Highly crystallization-induced emissive luminophores with mechanoluminescent features for two-photon harvesting fluorescence imaging and latent fingerprint identification
Fluorescence imaging can be employed in fields of medical treatment, astronomical exploration, and national defense security. Traditional fluorescence imaging often takes the single-photon techniques, which is...
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Article
Surface-derived phosphate layer on NiFe-layered double hydroxide realizes stable seawater oxidation at the current density of 1 A°cm−2
Seawater electrolysis, especially in coastlines, is widely considered as a sustainable way of making clean and high-purity H2 from renewable energy; however, the practical viability is challenged severely by the ...
