122 Result(s)

Article

Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks

Jonathan D. Diedrich, Qian Dong, Daniel C. Ferguson, Brennan P. Bergeron… in Leukemia (2024)

Article

B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4⁺T cell cytotoxicity through ESM1

Immunotherapy exhibited potential effects for advanced hepatocellular carcinoma, unfortunately, the clinical benefits are often countered by cancer adaptive immune suppressive response. Uncovering the mechanis...

Jiatao Li, Juan Feng, Ziyong Li, Yuanli Ni, Limei Liu, **a Lei… in npj Precision Oncology (2024)

Article

Is there really an accelerated phase of chronic myeloid leukaemia?

Robert Peter Gale, Qian Jiang, Jane F. Apperley, Andreas Hochhaus in Leukemia (2024)

Article

Point-of-care BCR::ABL1 transcript monitoring using capillary dried blood in chronic myeloid leukemia patients

Olga Sala-Torra, Lan Beppu, Qian Wu, Emily Welch, Erwin Berthier… in Leukemia (2024)

Article

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and...

Yun Yang, Qingya Liu, Meng Wang, Lang Li… in Signal Transduction and Targeted Therapy (2024)

Article

2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide⁺ (NAD⁺)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumu...

Fu Peng, Minru Liao, Wenke **, Wei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

A pathological joint–liver axis mediated by matrikine-activated CD4⁺ T cells

The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint dama...

Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen… in Signal Transduction and Targeted Therapy (2024)

Article

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β ...

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YA...

Hui Qian, Chen-Hong Ding, Fang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). This phase II study (Cli...

Huaqing Wang, Jifeng Feng, Yanyan Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Artificial intelligence-based assessment of PD-L1 expression in diffuse large B cell lymphoma

Diffuse large B cell lymphoma (DLBCL) is an aggressive blood cancer known for its rapid progression and high incidence. The growing use of immunohistochemistry (IHC) has significantly contributed to the detail...

Fang Yan, Qian Da, Hongmei Yi, Shijie Deng, Lifeng Zhu, Mu Zhou… in npj Precision Oncology (2024)

Article

Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate tumor suppressor mechanism and pa...

Qian Zhou, Yu Meng, Daishi Li, Lei Yao… in Signal Transduction and Targeted Therapy (2024)

Article

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a ...

Lu Qian, Yanli Zhu, Chao Deng, Zhenxing Liang… in Signal Transduction and Targeted Therapy (2024)

Article

Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma

This research explores the potential of multimodal fusion for the differential diagnosis of early-stage lung adenocarcinoma (LUAD) (tumor sizes < 2 cm). It combines liquid biopsy biomarkers, specifically extra...

Yanwei Zhang, Beibei Sun, Yinghong Yu, Jun Lu, Yuqing Lou… in npj Precision Oncology (2024)

Article

Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate mechanisms underlying I/R injury...

Meng Zhang, Qian Liu, Hui Meng, Hongxia Duan… in Signal Transduction and Targeted Therapy (2024)

Article

Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

Non-small cell lung cancer (NSCLC) ranks as one of the leading causes of cancer-related deaths worldwide. Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment, these drugs are...

Tao Yuan, Chenming Zeng, Jiawei Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages

Huili Chen, Shengyang Fu, **angyu Li, Meng Shi… in Signal Transduction and Targeted Therapy (2023)

Article

Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19

Previously, we identified an antibody combination A8G6 that showed promising efficacy in COVID-19 animal models and favorable safety profile in preclinical models as well as in a first-in-human trial. To evalu...

**aosong Li, Pai Peng, Haijun Deng, Qian Yang… in Signal Transduction and Targeted Therapy (2023)

Article

SARS-CoV-2 spike-specific T_FH cells exhibit unique responses in infected and vaccinated individuals

Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (T_FH) cells. H...

Rongzhang He, **ngyu Zheng, Jian Zhang, Bo Liu… in Signal Transduction and Targeted Therapy (2023)