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    Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

    Expression of the tumour suppressor PTEN in disseminated primary tumour cells is lost after tumour cells metastasize to the brain, with downregulation instigated by microRNAs from astrocytes, which are transfe...

    Lin Zhang, Siyuan Zhang, Jun Yao, Frank J. Lowery, Qingling Zhang… in Nature (2015)