9 Result(s)

Article

Histone deacetylase inhibitor resminostat in combination with sorafenib counteracts platelet-mediated pro-tumoral effects in hepatocellular carcinoma

In hepatocellular carcinoma (HCC), blood platelets have been linked to tumor growth, epithelial-to-mesenchymal transition (EMT), extrahepatic metastasis and a limited therapeutic response to the multikinase in...

Gundula Streubel, Sabine Schrepfer, Hannah Kallus, Ulrike Parnitzke… in Scientific Reports (2021)

Article

Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME)

The efficacy of PD-(L)1 blockade depends on the composition of the tumor immune microenvironment (TIME) and is generally higher in tumors with pre-existing cytotoxic T cells (CTL) than in those with low CTL nu...

Anne Catherine Bretz, Ulrike Parnitzke… in Journal for ImmunoTherapy of Cancer (2019)

Article

Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts

David Carbone, Michael Sharpnack, Kai He… in Journal of Translational Medicine (2018)

Article

A Review of Clinical Studies and Practical Guide for the Administration of Triplet Chemotherapy Regimens with Bevacizumab in First-line Metastatic Colorectal Cancer

Colorectal cancer is the third most common cancer worldwide. A significant proportion of patients presents with unresectable metastatic disease or develops metachronous metastases following surgical resection ...

Fotios Loupakis, Alexander Stein, Marc Ychou, Frank Hermann… in Targeted Oncology (2016)

Chapter and Conference Paper

Transformation Systems with Incremental Negative Application Conditions

In several application areas, Graph Transformation Systems (GTSs) are equipped with Negative Application Conditions (NACs) that specify “forbidden contexts”, in which the rules shall not be applied. The extens...

Andrea Corradini, Reiko Heckel… in Recent Trends in Algebraic Development Tec… (2013)

Chapter and Conference Paper

Concurrent Model Synchronization with Conflict Resolution Based on Triple Graph Grammars

Triple graph grammars (TGGs) have been used successfully to analyse correctness of bidirectional model transformations. Recently, also a corresponding formal approach to model synchronization has been presente...

Frank Hermann, Hartmut Ehrig, Claudia Ermel… in Fundamental Approaches to Software Enginee… (2012)

Chapter and Conference Paper

Incremental Service Composition Based on Partial Matching of Visual Contracts

Services provide access to software components that can be discovered dynamically via the Internet. The increasing number of services a requester may be able to use demand support for finding and selecting ser...

Muhammad Naeem, Reiko Heckel… in Fundamental Approaches to Software Enginee… (2010)

Chapter and Conference Paper

Transformation of Type Graphs with Inheritance for Ensuring Security in E-Government Networks

E-government services usually process large amounts of confidential data. Therefore, security requirements for the communication between components have to be adhered in a strict way. Hence, it is of main inte...

Frank Hermann, Hartmut Ehrig, Claudia Ermel in Fundamental Approaches to Software Enginee… (2009)

Chapter and Conference Paper

Information Preserving Bidirectional Model Transformations

Within model-driven software development, model transformation has become a key activity. It refers to a variety of operations modifying a model for various purposes such as analysis, optimization, and code ge...

Hartmut Ehrig, Karsten Ehrig, Claudia Ermel… in Fundamental Approaches to Software Enginee… (2007)