3 Result(s)

Article

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS

Gene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection...

Ianthe A. E. M. van Belzen, Casey Cai, Marc van Tuil, Shashi Badloe… in BMC Cancer (2023)

Article

Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics

Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intense therapy to counter a highly aggressive malignancy with survival rates of only 30–40%. The majority of patients initiall...

Tito Candelli, Pauline Schneider, Patricia Garrido Castro, Luke A. Jones… in Leukemia (2022)

Article

Combinatorial negative regulation of glucose-responsive genes in yeast

Ezra G. Jennings, Frank C.P. Holstege, John J. Wyrick, Richard A. Young in Nature Genetics (1999)