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  1. No Access

    Chapter

    Cultivation of Hepatocytes in a New Entrapment Reactor: a Potential Bioartificial Liver

    Liver failure is a major cause of mortality.1 Most patients admitted to an intensive care unit in liver failure do not survive. Currently, the only available treatment for refractory liver failure is hepatic tran...

    Wei-Shou Hu, Scott L. Nyberg… in Animal Cell Culture and Production of Biol… (1991)

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    Article

    Extended liver-specific functions of porcine hepatocyte spheroids entrapped in collagen gel

    The potential use of porcine hepatocytes in a bioartificial liver device requires large quantities of viable and highly active cells. To facilitate the scaling up of the system, liver specific activities of he...

    Arye Lazar, Henry J. Mann, Rory P. Remmel… in In Vitro Cellular & Developmental Biology … (1995)

  3. No Access

    Article

    Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids

    Freshly harvested rat hepatocytes form spheroids on uncoated positively charged polystyrene surfaces. Time lapse microscopy revealed that cell movement and reorganization were involved in spheroid formation. U...

    Madhusudan V. Peshwa, Florence J. Wu… in In Vitro Cellular & Developmental Biology … (1996)