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  1. No Access

    Article

    Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells

    Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue residency, its expression ...

    Raíssa Fonseca, Thomas N. Burn, Luke C. Gandolfo, Sapna Devi… in Nature Immunology (2022)

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    Article

    Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells

    Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism, contributing to cellular heterogeneity and disease. Diverse mutations are associated with diverse clinical phenotypes, suggesti...

    Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh… in Nature Genetics (2023)

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    Article

    Latent human herpesvirus 6 is reactivated in CAR T cells

    Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a ...

    Caleb A. Lareau, Yajie Yin, Katie Maurer, Katalin D. Sandor, Bence Daniel… in Nature (2023)