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Article
Open Access3D free-assembly modular microfluidics inspired by movable type printing
Reconfigurable modular microfluidics presents an opportunity for flexibly constructing prototypes of advanced microfluidic systems. Nevertheless, the strategy of directly integrating modules cannot easily fulf...
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Article
Open AccessRecent advances in acoustofluidic separation technology in biology
Acoustofluidic separation of cells and particles is an emerging technology that integrates acoustics and microfluidics. In the last decade, this technology has attracted significant attention due to its biocom...
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Article
The retroelement Lx9 puts a brake on the immune response to virus infection
The notion that mobile units of nucleic acid known as transposable elements can operate as genomic controlling elements was put forward over six decades ago1,2. However, it was not until the advancement of genomi...
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Article
Broadband photomultiplication-type polymer photodetectors and its application in light-controlled circuit
Photomultiplication-type polymer photodetectors (PM-PPDs) were achieved with polymer P3HT as donor and PY3Se-1V as acceptor based on structure of ITO/PEDOT:PSS/active layer/Al. The optimal weight ratio of P3HT...
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Article
16.3% Efficiency binary all-polymer solar cells enabled by a novel polymer acceptor with an asymmetrical selenophene-fused backbone
Despite the significant progress made recently in all-polymer solar cells (all-PSCs), it is still quite challenging to achieve high open-circuit voltage (Voc) and short-circuit current density (Jsc) simultaneousl...
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Article
Dilution effect for highly efficient multiple-component organic solar cells
Although the multiple-component (MC) blend strategy has been frequently used as a very effective way to improve the performance of organic solar cells (OSCs), there is a strong need to understand the fundament...
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Article
Open AccessBoron rich nanotube drug carrier system is suited for boron neutron capture therapy
Boron neutron capture therapy (BNCT) is a two-step therapeutic process that utilizes Boron-10 in combination with low energy neutrons to effectively eliminate targeted cells. This therapy is primarily used for...
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Article
Open AccessPseudo-bilayer architecture enables high-performance organic solar cells with enhanced exciton diffusion length
Solution-processed organic solar cells (OSCs) are a promising candidate for next-generation photovoltaic technologies. However, the short exciton diffusion length of the bulk heterojunction active layer in OSC...
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Article
2D metal–organic framework for stable perovskite solar cells with minimized lead leakage
Despite the notable progress in perovskite solar cells, maintaining long-term operational stability and minimizing potentially leaked lead (Pb2+) ions are two challenges that are yet to be resolved. Here we addre...
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Article
Open Access3D imaging of sex-sorted bovine spermatozoon locomotion, head spin and flagellum beating
With the advent of sperm sex sorting methods and computer-aided sperm analysis platforms, comparative 2D motility studies showed that there is no significant difference in the swimming speeds of X-sorted and Y...
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Article
Open AccessDistinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration
The PI 3-kinases (PI3K) are essential mediators of chemokine receptor signaling necessary for migration of chronic lymphocytic leukemia (CLL) cells and their interaction with tissue-resident stromal cells. Whi...
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Article
Open AccessLab-on-chip technology for chronic disease diagnosis
Various types of chronic diseases (CD) are the leading causes of disability and death worldwide. While those diseases are chronic in nature, accurate and timely clinical decision making is critically required....
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Article
Open AccessLabel-free 3D computational imaging of spermatozoon locomotion, head spin and flagellum beating over a large volume
We report a high-throughput and label-free computational imaging technique that simultaneously measures in three-dimensional (3D) space the locomotion and angular spin of the freely moving heads of microswimme...
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Article
Collective cell migration has distinct directionality and speed dynamics
When a constraint is removed, confluent cells migrate directionally into the available space. How the migration directionality and speed increase are initiated at the leading edge and propagate into neighborin...
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Article
Open AccessThe long non-coding RNA BC200 (BCYRN1) is critical for cancer cell survival and proliferation
BC200 is a long non-coding RNA expressed at high levels in the brain and elevated in a variety of tumour types. BC200 has a hypothesized role in translational regulation; however, to date the functional role o...
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Article
Open AccessFibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devices
Neutrophil trafficking in tissues critically regulates the body’s immune response. Neutrophil migration can either play a protective role in host defense or cause health problems. Fibroblast growth factor 23 (...
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Microfluidic-Based Live-Cell Analysis of NK Cell Migration In Vitro
Effector functions and cellular properties of natural killer (NK) cells are regulated by cellular and extracellular factors shaped by the microenvironments. NK cells express specific chemokine and non-chemokin...
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Article
Neutrophil migration under spatially-varying chemoattractant gradient profiles
Chemotaxis plays an important role in biological processes such as cancer metastasis, embryogenesis, wound healing, and immune response. Neutrophils are the frontline defenders against invasion of foreign micr...
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Article
A compact microfluidic system for cell migration studies
Microfluidic systems can better control cellular microenvironments and therefore are increasingly used for cell migration research. However, most existing systems are impractical to use without specialized fac...
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Article
DC Electric Fields Direct Breast Cancer Cell Migration, Induce EGFR Polarization, and Increase the Intracellular Level of Calcium Ions
Migration of cancer cells leads to invasion of primary tumors to distant organs (i.e., metastasis). Growing number of studies have demonstrated the migration of various cancer cell types directed by applied di...
