56 Result(s)
within
Feng Jiang**
Life Sciences
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Article
Identification of individual plants carrying viruses or a viroid in Pyrus betulifolia seedlings and virus-tested pear mother plants by group testing
Monitoring the sanitary status of a large population of vegetative propagation materials is a challenge because it requires expensive and time-consuming testing. Here we report a group testing strategy to iden...
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Climate change filtered out resource-acquisitive plants in a temperate grassland in Inner Mongolia, China
Global climate change has led to the decline of species and functional diversity in ecosystems, changing community composition and ecosystem functions. However, we still know little about how species with diff...
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Open AccessSAA suppresses α-PD-1 induced anti-tumor immunity by driving TH2 polarization in lung adenocarcinoma
Cancer stem cells (CSCs) are believed to be crucial in the initiation, progression, and recurrence of cancer. CSCs are also known to be more resistant to cancer treatments. However, the interaction between CSC...
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C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer
The clinical efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) is limited by the emergence of drug resistance. We hypothesise that restoring dysregulated circular RNAs under i...
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Open AccessMarked variations in gut microbial diversity, functions, and disease risk between wild and captive alpine musk deer
Maintaining a healthy status is crucial for the successful captive breeding of endangered alpine musk deer (Moschus chrysogaster, AMD), and captive breeding programs are beneficial to the ex-situ conservation and...
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Identification and prevalence investigation of cyathocotylid trematode (Trematoda: Digenea: Cyathocotylidae) in Carassius auratus in Wuhu, China
The family Cyathocotylidae trematode is a world-widely distributed parasite whose adults are mainly found in fish, reptiles, birds, and mammals in both freshwater and marine environments. However, little is kn...
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Open AccessThe super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma
Super-enhancers (SEs) are regulatory element clusters related to cell identity and disease. While the studies illustrating the function of SE-associated long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LU...
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PCSK9 Inhibition Regulates Infarction-Induced Cardiac Myofibroblast Transdifferentiation via Notch1 Signaling
Increasing evidence suggests that PCSK9 inhibition protects cardiomyocytes against ischemia-reperfusion injury after myocardial infarction. However, it is not clear whether PCSK9 inhibitor (PCSK9i) affects car...
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Open AccessAntibiotic treatment can exacerbate biofilm-associated infection by promoting quorum cheater development
Quorum cheating, a socio-microbiological process that is based on mutations in cell density-sensing (quorum-sensing) systems, has emerged as an important contributor to biofilm-associated infection in the lead...
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Open AccessIntegrated metabolomics and transcriptomics analysis during seed germination of waxy corn under low temperature stress
Waxy corn has a short growth cycle and high multiple crop** index. However, after being planted in early spring, late autumn and winter, it is susceptible to low temperature (LT), which reduces the emergence...
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Open AccessCNN-Siam: multimodal siamese CNN-based deep learning approach for drug‒drug interaction prediction
Drug‒drug interactions (DDIs) are reactions between two or more drugs, i.e., possible situations that occur when two or more drugs are used simultaneously. DDIs act as an important link in both drug developmen...
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Open AccessA long noncoding RNA HILinc1 enhances pear thermotolerance by stabilizing PbHILT1 transcripts through complementary base pairing
As global warming intensifies, heat stress has become a major environmental constraint threatening crop production and quality worldwide. Here, we characterize Heat-induced long intergenic noncoding RNA 1 (HILinc...
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Open AccessSelf-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC
Lung squamous cell carcinoma (LUSC) is a histological subtype of non-small cell lung cancer with the worse progression. SRY-Box Transcription Factor 2 (SOX2) copy number amplification (CNA) is the oncogenic dr...
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Open AccessRegulation of Semaphorin3A in the process of cutaneous wound healing
Semaphorin 3A (Sema3A) has been recognized as a crucial regulator of morphogenesis and homeostasis over a wide range of organ systems. However, its function in cutaneous wound healing is poorly understood. In ...
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Article
Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis
Breast cancer stem cells (BCSCs) are positively correlated with the metastasis, chemoresistance, and recurrence of breast cancer. However, there are still no drugs targeting BCSCs in clinical using for breast ...
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Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica
The extracellular contractile injection systems (eCISs) are encoded in the genomes of a large number of bacteria and archaea. We have previously characterized the overall structure of Photorhabdus Virulence Casse...
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Open AccessComparative analysis of gut microbial composition and potential functions in captive forest and alpine musk deer
Gut microbiota forms a unique microecosystem and performs various irreplaceable metabolic functions for ruminants. The gut microbiota is important for host health and provides new insight into endangered speci...
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Open AccessAnalysis of allergen components and identification of bioactivity of HSP70 in pollen of Populus deltoides
Allergies caused by pollen from Populus deltoides are common, but the allergic components are still unclear.
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Open AccessExposure to hypoxia causes stress erythropoiesis and downregulates immune response genes in spleen of mice
The spleen is the largest secondary lymphoid organ and the main site where stress erythropoiesis occurs. It is known that hypoxia triggers the expansion of erythroid progenitors; however, its effects on spleni...
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Open AccessTranscription initiation of distant core promoters in a large-sized genome of an insect
Core promoters have a substantial influence on various steps of transcription, including initiation, elongation, termination, polyadenylation, and finally, translation. The characterization of core promoters i...
