68 Result(s)
within
Feng Jiang**
Biomedicine
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Article
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and pathogenicity. Given the emergence of increasingly drug-resistant str...
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Article
Open AccessEffects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets
Metastasis remains the principal cause of cancer-related lethality despite advancements in cancer treatment. Dysfunctional epigenetic alterations are crucial in the metastatic cascade. Among these, super-enhan...
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Article
Effect of CTLA-4 Inhibition on Inflammation and Apoptosis After Spinal Cord Injury
Spinal cord injury (SCI) encompasses various pathological processes, notably neuroinflammation and apoptosis, both of which play significant roles. CTLA-4, a well-known immune molecule that suppresses T cell-m...
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Open AccessPredictive value of delta radiomics in xerostomia after chemoradiotherapy in patients with stage III-IV nasopharyngeal carcinoma
Xerostomia is one of the most common side effects in nasopharyngeal carcinoma (NPC) patients after chemoradiotherapy. To establish a Delta radiomics model for predicting xerostomia secondary to chemoradiothera...
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Article
Silencing PKM2 Attenuates Brain Injury Induced by Status Epilepticus by Inhibiting the AKT/mTOR Pathway and the NLRP3 Inflammasome
PKM2 is a glycolytic pyruvate kinase isoenzyme, and its role in neurological diseases has been published. However, the role and mechanism of PKM2 in the process of status epilepticus have not been reported. Th...
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Article
Bioinformatics Analysis and Identification of Ferroptosis-Related Hub Genes in Intervertebral Disc Degeneration
Approximately 80% of individuals encounter lower back pain (LBP), a prevalent clinical issue largely attributed to intervertebral disc degeneration (IDD). Ferroptosis is an iron-dependent lipid peroxidation-dr...
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Identification of the Shared Gene Signatures and Biological Mechanisms in Hyperplastic Enlarged Lobular Units and Breast Cancer
Breast cancer is a common cancer worldwide. Hyperplastic enlarged lobular units (HELUs) are common changes in the breasts of adult women. HELUs may be closely related to the occurrence and development of breas...
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Open AccessPrediction of Oncomelania hupensis distribution in association with climate change using machine learning models
Oncomelania hupensis is the sole intermediate host of Schistosoma japonicum. Its emergence and recurrence pose a constant challenge to the elimination of schistosomiasis in China. It is important to accurately pr...
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Open AccessPiperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity
The failure of novel therapies effective in preclinical animal models largely reflects the fact that current models do not really mimic the pathological/therapeutic features of glioblastoma (GBM), in which the...
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Article
Open AccessAssociation of virome dynamics with mosquito species and environmental factors
The pathogenic viruses transmitted by mosquitoes cause a variety of animal and human diseases and public health concerns. Virome surveillance is important for the discovery, and control of mosquito-borne patho...
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Open AccessEcological interactions and the underlying mechanism of anammox and denitrification across the anammox enrichment with eutrophic lake sediments
Increasing attention has recently been devoted to the anaerobic ammonium oxidation (anammox) in eutrophic lakes due to its potential key functions in nitrogen (N) removal for eutrophication control. However, s...
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Open AccessSingle-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
This study aimed to delineate the cell heterogeneity in the bone-implant interface and investigate the fibroblast responses to implant-associated S. aureus infection.
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Open AccessROS generation and p-38 activation contribute to montmorillonite-induced corneal toxicity in vitro and in vivo
Montmorillonite (Mt) and its derivatives are now widely used in industrial and biomedical fields. Therefore, safety assessments of these materials are critical to protect human health after exposure; however, ...
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Article
Tissue-resident immune cells in the pathogenesis of multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which genetic and environmental factors contribute to disease progression. Both innate and adaptive i...
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Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders
Observational studies have reported the correlations between brain imaging-derived phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal is uncertain. We conducted bidirect...
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Article
Assessment of quality deviation of pork and salmon due to temperature fluctuations during superchilling
Superchilling is an emerging technology for meat preservation; however, the temperature changes during the process have been commonly ignored. Thus, the effects of temperature fluctuations on meat quality duri...
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Article
Basic Phenoty** of Male Fertility from 2019 to 2020 at the Human Sperm Bank of Fudan University
The aim of this cross-sectional survey was to analyze the semen parameters of volunteers from the Human Sperm Bank of Fudan University, as well as the related factors influencing these parameters. From January...
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Article
Open AccessCancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures
Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment (TME) with diverse functions such as extracellular matrix (ECM) remodeling, modulation of metabolism and angiogenesis,...
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Open AccessIdentification of severe fever with thrombocytopenia syndrome virus genotypes in patients and ticks in Liaoning Province, China
Severe fever with thrombocytopenia syndrome (SFTS), caused by the SFTS virus (SFTSV), is an acute infectious disease transmitted by ticks that has recently been identified. There are no reports of epidemic ser...
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Article
A Preliminary Study on the Evaluation of Human Sperm Head Morphology with a Domestic Digital Holographic Image System
The head of sperm was imaged with domestic digital holographic microscopy (DHM), and then the quantitative three-dimensional size information of normal sperm and teratozoospermic sperm was compared and analyze...
