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  1. Article

    Open Access

    Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics

    Aging is a prominent risk factor for diverse diseases; therefore, an in-depth understanding of its physiological mechanisms is required. Nonhuman primates, which share the closest genetic relationship with hum...

    Yunpeng Liu, Shuaiyao Lu, **g Yang, Yun Yang, Li Jiao, **gwen Hu in BMC Genomics (2024)

  2. No Access

    Article

    Structural insights into branch site proofreading by human spliceosome

    Selection of the pre-mRNA branch site (BS) by the U2 small nuclear ribonucleoprotein (snRNP) is crucial to prespliceosome (A complex) assembly. The RNA helicase PRP5 proofreads BS selection but the underlying ...

    **aofeng Zhang, **echao Zhan, Tong Bian in Nature Structural & Molecular Biology (2024)

  3. Article

    Open Access

    USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway

    Ubiquitin-specific protease 3 (USP3) plays an important role in the progression of various tumors. However, the role of USP3 in osteosarcoma (OS) remains poorly understood. The aim of this study was to explore...

    Anan Li, Shijiang Wang, Jiangbo Nie, Shining **ao, **nsheng **e in Cell Death & Disease (2024)

  4. No Access

    Article

    DNA loo** mediates cooperative transcription activation

    Transcription factors respond to multilevel stimuli and co-occupy promoter regions of target genes to activate RNA polymerase (RNAP) in a cooperative manner. To decipher the molecular mechanism, here we report...

    Shu-**g Han, Yong-Liang Jiang, Lin-Lin You in Nature Structural & Molecular Biology (2024)

  5. Article

    Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics

    **aoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding in Nature Cell Biology (2024)

  6. No Access

    Article

    Human SIDT1 mediates dsRNA uptake via its phospholipase activity

    Cai-Rong Sun, Da Xu, Fengrui Yang, Zhuanghao Hou, Yuyao Luo, Chen-Yu Zhang in Cell Research (2024)

  7. No Access

    Article

    MYB44 plays key roles in regulating plant responses to abiotic and biotic stress, metabolism, and development

    MYB44 played key roles in plant responses to abiotic and biotic stress and important roles in plant metabolism and development. At present, the function of MYB44 has not been systemically summarized in plants....

    Fenghua Wang, Feng Yang, Dengfeng Zhu in Journal of Plant Biochemistry and Biotechn… (2023)

  8. Article

    Open Access

    Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics

    Plague, caused by Yersinia pestis, is a zoonotic disease that can reemerge and cause outbreaks following decades of latency in natural plague foci. However, the genetic diversity and spread pattern of Y. pestis d...

    **gliang Qin, Yarong Wu, Liyuan Shi, **ujuan Zuo in Communications Biology (2023)

  9. No Access

    Article

    TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat

    Grain development is a crucial determinant of yield and quality in bread wheat (Triticum aestivum L.). However, the regulatory mechanisms underlying wheat grain development remain elusive. Here we report how TaMA...

    Guoyu Liu, Runqi Zhang, Sen Li, Rehmat Ullah, Feng** Yang in Science China Life Sciences (2023)

  10. No Access

    Article

    Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

    Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated diseases. Determining the fun...

    Christopher C. Pan, Raquel Maeso-Díaz, Tylor R. Lewis, Kun **ang in Cell Research (2023)

  11. Article

    Open Access

    Effect of miR-149-5p on intramuscular fat deposition in pigs based on metabolomics and transcriptomics

    As one of the important traits in pig production, meat quality has important research significance and value. Intramuscular fat (IMF) content is one of the most important factors affecting pork quality. Many e...

    Yingke Liu, Yilin Wei, Yaqing Dou, Chenlei Li, Chenglei Song, Zhe Zhang in BMC Genomics (2023)

  12. Article

    Open Access

    Effects of adding corn steep liquor on bacterial community composition and carbon and nitrogen transformation during spent mushroom substrate composting

    Carbon and nitrogen are essential energy and nutrient substances in the composting process. Corn steep liquor (CSL) is rich in soluble carbon and nitrogen nutrients and active substances and is widely used in ...

    Ning Sun, Bowen Fan, Fengjun Yang, Liqin Zhao, Mengmeng Wang in BMC Microbiology (2023)

  13. Article

    Open Access

    Transcriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs

    N6-methyladenosine (m6A) refers to the methylation modification of N6 position of RNA adenine, a dynamic reversible RNA epigenetic modification that plays an important regulatory role in a variety of life process...

    Yaqing Dou, Yilin Wei, Zhe Zhang, Chenlei Li, Chenglei Song, Yingke Liu in BMC Genomics (2023)

  14. Article

    Open Access

    The model diatom Phaeodactylum tricornutum provides insights into the diversity and function of microeukaryotic DNA methyltransferases

    Cytosine methylation is an important epigenetic mark involved in the transcriptional control of transposable elements in mammals, plants and fungi. The Stramenopiles-Alveolate-Rhizaria (SAR) lineages are a maj...

    Antoine Hoguin, Feng Yang, Agnès Groisillier, Chris Bowler in Communications Biology (2023)

  15. Article

    Open Access

    The genome of a vestimentiferan tubeworm (Ridgeia piscesae) provides insights into its adaptation to a deep-sea environment

    Vestimentifera (Polychaeta, Siboglinidae) is a taxon of deep-sea worm-like animals living in deep-sea hydrothermal vents, cold seeps, and organic falls. The morphology and lifespan of Ridgeia piscesae, which is t...

    Muhua Wang, Lingwei Ruan, Meng Liu, Zixuan Liu, Jian He, Long Zhang in BMC Genomics (2023)

  16. No Access

    Article

    Phase separation of EB1 guides microtubule plus-end dynamics

    In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule dynamics and are essential for cellular dynamics and organelle movements. EB proteins modulate structural transitions at gr...

    **aoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding in Nature Cell Biology (2023)

  17. Article

    Open Access

    A comparative transcriptomic analysis reveals a coordinated mechanism activated in response to cold acclimation in common vetch (Vicia sativa L.)

    Due to its strong abiotic stress tolerance, common vetch is widely cultivated as a green manure and forage crop in grass and crop rotation systems. The comprehensive molecular mechanisms activated in common ve...

    Rui Dong, Ben Luo, Li Tang, Qiu-xia Wang, Zhong-Jie Lu, Chao Chen in BMC Genomics (2022)

  18. Article

    Open Access

    ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis

    Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene e...

    Wenjun Kuang, Hao **, Feng Yang, **ying Chen, Jianzhao Liu, Ting Li in Cell Discovery (2022)

  19. Article

    Open Access

    Comparative chromosome maps between the stone curlew and three ciconiiform species (the grey heron, little egret and crested ibis)

    Previous cytogenetic studies show that the karyotypes of species in Ciconiiformes vary considerably, from 2n = 52 to 78. Their karyotypes include different numbers of small to minute bi-armed chromosomes that ...

    **huan Wang, Weiting Su, Yi Hu, Shengbin Li in BMC Ecology and Evolution (2022)

  20. No Access

    Article

    Evidence of early iron smelting on the Tibetan plateau

    This paper discusses the origin of early use and production technology of iron in Tibet through the analysis of the iron objects and slags excavated from the Kaji cemetery at the Piyangdongga site, **zang, Chi...

    Yuniu Li, Mengyi Zhang, Shuai Li, Feng Yang in Archaeological and Anthropological Sciences (2022)

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