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Open AccessAnalysis of the aging-related biomarker in a nonhuman primate model using multilayer omics
Aging is a prominent risk factor for diverse diseases; therefore, an in-depth understanding of its physiological mechanisms is required. Nonhuman primates, which share the closest genetic relationship with hum...
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Article
Structural insights into branch site proofreading by human spliceosome
Selection of the pre-mRNA branch site (BS) by the U2 small nuclear ribonucleoprotein (snRNP) is crucial to prespliceosome (A complex) assembly. The RNA helicase PRP5 proofreads BS selection but the underlying ...
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Article
Open AccessUSP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway
Ubiquitin-specific protease 3 (USP3) plays an important role in the progression of various tumors. However, the role of USP3 in osteosarcoma (OS) remains poorly understood. The aim of this study was to explore...
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Article
DNA loo** mediates cooperative transcription activation
Transcription factors respond to multilevel stimuli and co-occupy promoter regions of target genes to activate RNA polymerase (RNAP) in a cooperative manner. To decipher the molecular mechanism, here we report...
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Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
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Human SIDT1 mediates dsRNA uptake via its phospholipase activity
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MYB44 plays key roles in regulating plant responses to abiotic and biotic stress, metabolism, and development
MYB44 played key roles in plant responses to abiotic and biotic stress and important roles in plant metabolism and development. At present, the function of MYB44 has not been systemically summarized in plants....
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Open AccessGenomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics
Plague, caused by Yersinia pestis, is a zoonotic disease that can reemerge and cause outbreaks following decades of latency in natural plague foci. However, the genetic diversity and spread pattern of Y. pestis d...
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TaMADS29 interacts with TaNF-YB1 to synergistically regulate early grain development in bread wheat
Grain development is a crucial determinant of yield and quality in bread wheat (Triticum aestivum L.). However, the regulatory mechanisms underlying wheat grain development remain elusive. Here we report how TaMA...
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Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing
Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment, leading to chronic inflammation and age-associated diseases. Determining the fun...
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Open AccessEffect of miR-149-5p on intramuscular fat deposition in pigs based on metabolomics and transcriptomics
As one of the important traits in pig production, meat quality has important research significance and value. Intramuscular fat (IMF) content is one of the most important factors affecting pork quality. Many e...
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Open AccessEffects of adding corn steep liquor on bacterial community composition and carbon and nitrogen transformation during spent mushroom substrate composting
Carbon and nitrogen are essential energy and nutrient substances in the composting process. Corn steep liquor (CSL) is rich in soluble carbon and nitrogen nutrients and active substances and is widely used in ...
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Open AccessTranscriptome-wide analysis of RNA m6A methylation regulation of muscle development in Queshan Black pigs
N6-methyladenosine (m6A) refers to the methylation modification of N6 position of RNA adenine, a dynamic reversible RNA epigenetic modification that plays an important regulatory role in a variety of life process...
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Open AccessThe model diatom Phaeodactylum tricornutum provides insights into the diversity and function of microeukaryotic DNA methyltransferases
Cytosine methylation is an important epigenetic mark involved in the transcriptional control of transposable elements in mammals, plants and fungi. The Stramenopiles-Alveolate-Rhizaria (SAR) lineages are a maj...
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Open AccessThe genome of a vestimentiferan tubeworm (Ridgeia piscesae) provides insights into its adaptation to a deep-sea environment
Vestimentifera (Polychaeta, Siboglinidae) is a taxon of deep-sea worm-like animals living in deep-sea hydrothermal vents, cold seeps, and organic falls. The morphology and lifespan of Ridgeia piscesae, which is t...
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Article
Phase separation of EB1 guides microtubule plus-end dynamics
In eukaryotes, end-binding (EB) proteins serve as a hub for orchestrating microtubule dynamics and are essential for cellular dynamics and organelle movements. EB proteins modulate structural transitions at gr...
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Open AccessA comparative transcriptomic analysis reveals a coordinated mechanism activated in response to cold acclimation in common vetch (Vicia sativa L.)
Due to its strong abiotic stress tolerance, common vetch is widely cultivated as a green manure and forage crop in grass and crop rotation systems. The comprehensive molecular mechanisms activated in common ve...
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Open AccessALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis
Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene e...
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Open AccessComparative chromosome maps between the stone curlew and three ciconiiform species (the grey heron, little egret and crested ibis)
Previous cytogenetic studies show that the karyotypes of species in Ciconiiformes vary considerably, from 2n = 52 to 78. Their karyotypes include different numbers of small to minute bi-armed chromosomes that ...
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Evidence of early iron smelting on the Tibetan plateau
This paper discusses the origin of early use and production technology of iron in Tibet through the analysis of the iron objects and slags excavated from the Kaji cemetery at the Piyangdongga site, **zang, Chi...