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Article
Enhancing hydrolysis of lignocellulosic biomass through molecular modification of lytic polysaccharide monooxygenase from Aspergillus niger
Lytic polysaccharide monooxygenase (LPMO) of Auxiliary Activity 9 family has great potential for lignocellulose biomass degradation, and obtaining AA9 LPMOs with high catalytic activity and thermalstability is...
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Article
Open AccessGenome-wide analysis of the SWEET gene family in Hemerocallis citrina and functional characterization of HcSWEET4a in response to salt stress
Sugars will be eventually effluxed transporters (SWEETs) have been confirmed to play diverse physiological roles in plant growth, development and stress response. However, the characteristics and functions of the...
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Article
Self-expanding intracranial drug-eluting stent system in patients with symptomatic intracranial atherosclerotic stenosis: initial experience and midterm angiographic follow-up
Symptomatic intracranial atherosclerotic stenosis (ICAS) is a major cause of ischemic stroke worldwide. In patients undergoing endovascular treatment for ICAS, in-stent restenosis (ISR) is associated with isch...
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Article
Open AccessGenome wide identification of novel DNA methylation driven prognostic markers in colorectal cancer
Colorectal cancer (CRC) stands as a major contributor to cancer-related fatalities within China. There is an urgent need to identify accurate biomarkers for recurrence predicting in CRC. Reduced representation...
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Article
Sample Size Determination and Study Design Impact on Dose-Scale Pharmacodynamic Bioequivalence: a Case Study Using Orlistat
Dose-scale pharmacodynamic bioequivalence is recommended for evaluating the consistency of generic and innovator formulations of certain locally acting drugs, such as orlistat. This study aimed to investigate ...
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Article
Luminance domain-guided low-light image enhancement
Images captured under low-light conditions often suffer from low contrast, high noise, and uneven brightness due to nightlight, backlight, and shadow. These challenges make it difficult to use them as high-qua...
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Article
Deformable shape matching with multiple complex spectral filter operator preservation
The functional maps framework has achieved remarkable success in non-rigid shape matching. However, the traditional functional map representations do not explicitly encode surface orientation, which can easily...
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Article
Open AccessRandom-access wide-field mesoscopy for centimetre-scale imaging of biodynamics with subcellular resolution
Benefitting from the advantages of high imaging throughput and low cost, wide-field microscopy has become indispensable in biomedical studies. However, it remains challenging to record biodynamics with a large...
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Article
Open AccessThe association between endometrial polyps and insulin resistance from the expression of PI3K and AKT proteins perspective
Insulin resistance (IR) induces hyperinsulinemia, which activates downstream signaling pathways such as the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathway, ultimately leading to abnormal pro...
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Article
Soil Organic Matter and Total Nitrogen Reshaped Root-Associated Bacteria Community and Synergistic Change the Stress Resistance of Codonopsis pilosula
The stress resistance of medicinal plants is essential to the accumulation of pharmacological active ingredients, but the regulation mechanism of biological factors and abiotic factors on medicinal plants is s...
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Article
Three-party evolutionary game-based analysis and stability enhancement of improved PBFT consensus mechanism
Within the intricate dynamics of a blockchain system, participants with bounded rationality may engage in dishonest behavior, thereby disrupting the consensus of the system in the absence of incentive mechanis...
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Article
Comparative effects of different metals on the Japanese medaka embryos and larvae
Rapid evaluation of the toxicity of metals using fish embryo acute toxicity is facilitative to ecological risk assessment of aquatic organisms. However, this approach has seldom been utilized for the comparati...
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Article
Comparative transcriptomics revealed the mechanism of Stenotrophomonas rhizophila JC1 response and biosorption to Pb2+
Nowadays, there is limited research focusing on the biosorption of Pb2+ through microbial process, particularly at the level of gene expression. To overcome this knowledge gap, we studied the adsorption capacity ...
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Article
How geographic accessibility and rural governance mitigate the impact of multiple risks on rural households’ well-being: Evidence from the Dabie Mountains in China
Despite previous studies on the interconnectedness of livelihood risks and human well-being, limited emphasis has been placed on the influence of geographic accessibility and rural governance on the well-being...
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Article
Dissimilar friction stir welding of 2219-T8 and 2195-T8 aluminum alloys for fuel tanks: part II—effect of multi-pass repair welding
During the fabrication of fuel tanks by adopting friction stir welding (FSW), welding defects were almost unavoidable. The multi-pass repair FSW is the preferred repair welding technique for fuel tanks. Howeve...
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Article
Open AccessGlycolysis inhibition induces anti-tumor central memory CD8+T cell differentiation upon combination with microwave ablation therapy
Minimally invasive thermal therapy is a successful alternative treatment to surgery in solid tumors with high complete ablation rates, however, tumor recurrence remains a concern. Central memory CD8+ T cells (TCM
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Article
Stand structural diversity and edaphic properties regulate aboveground biomass of Abies fargesii var. faxoniana primary forest on the eastern Qinghai-Tibetan Plateau
Plant aboveground biomass reflects the resilience of ecosystem productivity to different environmental factors and plays an important role in biodiversity and ecosystem carbon cycles. Although many studies hav...
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Article
An autologous duraplasty in situ technique in the treatment of Chiari malformation Type I: a prospective study
Our study aims to prospectively compare an autologous duraplasty in situ technique (IS group) with the synthetic dural graft duraplasty (SDG group) to clarify the effectiveness and superiority of the former in...
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Article
Open AccessMultiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant neoplasm characterized by a poor prognosis and limited therapeutic strategy. The PDAC tumor microenvironment presents a complex heterogeneity, wher...
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Article
Elevational Patterns and Drivers of Leaf Carbon, Nitrogen, and Phosphorus Stoichiometry in an Alpine-Gorge Region on the Eastern Qinghai-Tibetan Plateau
The study aimed to reveal the elevational patterns and drivers of leaf carbon (C), nitrogen (N), and phosphorus (P) concentrations and their stoichiometry at both the individual and community levels in the alp...
