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  1. Article

    Open Access

    Pyroptosis of Salmonella Typhimurium-infected macrophages was suppressed and elimination of intracellular bacteria from macrophages was promoted by blocking QseC

    QseC is a membrane-bound histidine sensor kinase found in Gram-negative pathogens and is involved in the regulation of bacterial virulence. LED209, a QseC-specific inhibitor, significantly inhibits the virulen...

    Zhi Li, Qing Zheng, **aoyan Xue, **n Shi, Ying Zhou, Fei Da, Di Qu… in Scientific Reports (2016)

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  2. Article

    Reversion of antibiotic resistance by inhibiting mecA in clinical methicillin-resistant Staphylococci by antisense phosphorothioate oligonucleotide

    Methicillin-resistant Staphylococci (MRS), methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) have become a challenging problem in nosocomial infections...

    **gru Meng, Gonghao He, Hui Wang, Min Jia, Xue Ma, Fei Da… in The Journal of Antibiotics (2015)

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  3. No Access

    Article

    Comparison of microplate and macrodilution methods in time–kill study of new antimicrobial drugs

    In consideration of high production costs of new antimicrobial drugs, a more convenient and economical method for time–kill study is urgently required. In the present experiment, we attempted to demonstrate th...

    Ying Zhou, Zheng Hou, Chao Fang, **aoyan Xue, Fei Da, Yukun Wang… in Folia Microbiologica (2013)

  4. No Access

    Article

    Amino-Terminated Generation 2 Poly(amidoamine) Dendrimer as a Potential Broad-Spectrum, Nonresistance-Inducing Antibacterial Agent

    The treatment of septicemia caused by antibiotic-resistant bacteria is a great challenge in the clinic. Because traditional antibiotics inevitably induce bacterial resistance, which is responsible for many tre...

    **aoyan Xue, **aoqing Chen, **nggang Mao, Zheng Hou, Ying Zhou, Hui Bai… in The AAPS Journal (2013)