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  1. Article

    Open Access

    Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulatin...

    Weirong Chen, So-Hee Hong, Scott A. Jenks, Fabliha A. Anam in Nature Communications (2024)

  2. Article

    Open Access

    Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID

    While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations, understanding ...

    Matthew C. Woodruff, Kevin S. Bonham, Fabliha A. Anam in Nature Communications (2023)

  3. Article

    Open Access

    Dysregulated naive B cells and de novo autoreactivity in severe COVID-19

    Severe SARS-CoV-2 infection1 has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic25. More recently, these responses have been associated with the emerge...

    Matthew C. Woodruff, Richard P. Ramonell, Natalie S. Haddad, Fabliha A. Anam in Nature (2022)