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  1. Article

    Open Access

    Fatal anaphylaxis registries data support changes in the who anaphylaxis mortality coding rules

    Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction. The difficulty of coding anaphylaxis fatalities under the World Health Organization (WHO) International Cl...

    Luciana Kase Tanno, F. Estelle R. Simons… in Orphanet Journal of Rare Diseases (2017)

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  2. No Access

    Article

    Sublingual Diffusion of Epinephrine Microcrystals from Rapidly Disintegrating Tablets for the Potential First-Aid Treatment of Anaphylaxis: In Vitro and Ex Vivo Study

    For the first-aid treatment of anaphylaxis, epinephrine (Epi) 0.3 mg intramuscular (IM) injection in the thigh is the drug of choice. Epi auto-injectors are widely recommended for anaphylaxis treatment in comm...

    Mutasem M. Rawas-Qalaji, Shima Werdy, Ousama Rachid… in AAPS PharmSciTech (2015)

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    Article

    Hydroxyzine from topical phospholipid liposomal formulations: Evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model

    Hydroxyzine, an effective but sedating H1-antihistamine is given orally to treat allergic skin disorders. This study was performed to assess the peripheral H1-antihistaminic activity and extent of systemic absorp...

    Abeer A W Elzainy, **aochen Gu, F. Estelle R. Simons, Keith J. Simons in AAPS PharmSci (2015)

  4. No Access

    Article

    Dissolution Testing of Sublingual Tablets: A Novel In Vitro Method

    In the sublingual (SL) cavity, compared with the gastrointestinal tract, tablets are subjected to minimal physiological agitation, and a limited volume of saliva is available to facilitate disintegration and d...

    Ousama Rachid, Mutasem Rawas-Qalaji, F. Estelle R. Simons… in AAPS PharmSciTech (2011)

  5. No Access

    Article

    An Electronic Tongue: Evaluation of the Masking Efficacy of Sweetening and/or Flavoring Agents on the Bitter Taste of Epinephrine

    An epinephrine (E) tablet is under development for sublingual (SL) administration for the first-aid treatment of anaphylaxis; however, the inherent bitterness of E may hinder acceptability by patients, especia...

    Ousama Rachid, F. Estelle R. Simons, Mutasem Rawas-Qalaji… in AAPS PharmSciTech (2010)

  6. No Access

    Article

    Cetirizine from topical phosphatidylcholine-hydrogenated liposomes: Evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model

    Cetirizine, an effective, minimally sedating, second-generation H1-antihistamine is widely used orally to treat allergic skin disorders. This study was performed to assess the peripheral H1-antihistaminic activit...

    Abeer A. W. Elzainy, **aochen Gu, F. Estelle R. Simons, Keith J. Simons in The AAPS Journal (2004)

  7. No Access

    Article

    Fexofenadine

    F. Estelle R. Simons in Drugs (1998)

  8. No Access

    Article

    Effect of Cimetidine on the Pharmacokinetics and Pharmacodynamics of Chlorpheniramine and Diphenhydramine in Rabbits

    Purpose. The effects of concomitant administration of the H2-receptor antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1-receptor antagonists chlorpheniramine and diphenhydramine were s...

    Keith J. Simons, Xueyu Chen, Terry G. Eraser… in Pharmaceutical Research (1996)

  9. No Access

    Article

    Effect of the H2-Receptor Antagonist Cimetidine, on the Pharmacokinetics and Pharmacodynamics of the H1-Receptor Antagonists Hydroxyzine and Cetirizine in Rabbits

    The effects of coadministration of the H2-receptor antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1 receptor antagonists hydroxyzine and cetirizine were studied in rabbits. A single do...

    Xueyu Chen, F. Estelle R. Simons, Keith J. Simons in Pharmaceutical Research (1994)