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Chapter and Conference Paper
Aktivierung von Snail und Sonic Hedgehog bei neuroendokrinen Tumoren des Ileums
The transcription factor Snail represses E-cadherin and induces epithelial-mesenchymal transition (EMT), a process also exploited by invasive cancer cells. Aberrant Hedgehog (Hh) signaling was recently observe...
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Chapter and Conference Paper
Die Überexpression von Sonic Hedgehog führt zur epithelialen-mesenchymalen Transition im adulten Pankreas der Maus
The Hedgehog signaling pathway plays a central in carcinogenesis in tumors of endodermal origin, including pancreatic cancer. To directly determine the effect of sustained Hedgehog activity on mature mammalian...