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  1. Article

    Open Access

    Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo

    Rhabdomyosarcoma (RMS) is a paediatric soft-tissue sarcoma arising from skeletal muscle precursors coexpressing markers of proliferation and differentiation. Inducers of myogenic differentiation suppress RMS t...

    L Raimondi, R Ciarapica, M De Salvo, F Verginelli… in Cell Death & Differentiation (2012)

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  2. Article

    Open Access

    The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)

    The Polycomb group (PcG) proteins regulate stem cell differentiation via the repression of gene transcription, and their deregulation has been widely implicated in cancer development. The PcG protein Enhancer ...

    R Ciarapica, M De Salvo, E Carcarino, G Bracaglia, L Adesso, P P Leoncini… in Oncogene (2014)

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  3. Article

    Open Access

    Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia

    Deregulation of the miR-15a/16-1 cluster has a key role in the pathogenesis of chronic lymphocytic leukemia (CLL), a clinically heterogeneous disease with indolent and aggressive forms. The miR-15a/16-1 locus is ...

    A Veronese, F Pepe, J Chiacchia, S Pagotto, P Lanuti, S Veschi, M Di Marco… in Leukemia (2015)

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