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Article
Accuracy of thermocouples in radiant-heat testing
Results of an investigation of the accuracy of iron-constantan thermocouples in measuring transient surface temperatures produced by radiant heating on metallic specimens are given. The criterion of thermocoup...
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Article
Relationship between D 1 dopamine receptors, adenylate cyclase, and the electrophysiological responses of rat nucleus accumbens neurons
The electrophysiological effects of three selective D 1 dopamine (DA) receptor agonists, which exhibit different potencies and efficacies for stimulation of adenylate cyclase, were compared in the rat nucleus ...
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Article
Strategies for the treatment of cystathionine β-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years
Strategies for the treatment of cystathionine β-synthase (CBS) deficiency include (1) increasing residual enzyme activity by giving pyridoxine in those patients with vitamin responsive variants, (2) reducing ...
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Article
Adaptations in the mesoaccumbens dopamine system resulting from repeated administration of dopamine D1 and D2 receptor-selective agonists: relevance to cocaine sensitization
The mesoaccumbens dopamine (DA) system is intricately involved in sensitization to the locomotor stimulant effects of cocaine. Among the adaptations implicated in cocaine sensitization are transient subsensit...
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Article
Pharmacological reversal of behavioral and cellular indices of cocaine sensitization in the rat
Rationale and objectives: Behavioral sensitization has been proposed as an animal model for the intensification of drug craving in cocaine addiction. Interactions between dopamine and glutamate systems are impor...
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Article
Randomised controlled trial of essential fatty acid supplementation in phenylketonuria
The long-chain polyunsaturated fatty acids (LC-PUFA) status of children with PKU is often compromised. LC-PUFA, which are important fatty acids in the development of the CNS, can be synthesised endogenously fr...
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Article
Variation in the Social Systems of Extant Hominoids: Comparative Insight into the Social Behavior of Early Hominins
The observed social systems of extant apes and humans suggest that the common ancestral state for Miocene hominoids was living in multimale–multifemale groups that exhibited a tendency to fission and fusion in...
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Article
Unsuccessful treatment of severe pyruvate carboxylase deficiency with triheptanoin
Pyruvate carboxylase (PC) deficiency (OMIM 266150) is an autosomal recessive disorder that usually presents with lactic acidaemia and severe neurological dysfunction, leading to death in infancy. Because the e...
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Article
Open AccessTwo decades of climate change alters seed longevity in an alpine herb: implications for ex situ seed conservation
Climate warming in mountain areas is increasing faster than the global average, threatening alpine plants. Climate affects many traits including seeds, the longevity of which is important for conservation, fac...
