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    CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity

    Current methods can illuminate the genome-wide activity of CRISPR–Cas9 nucleases, but are not easily scalable to the throughput needed to fully understand the principles that govern Cas9 specificity. Here we d...

    Cicera R. Lazzarotto, Nikolay L. Malinin, Yichao Li, Ruochi Zhang… in Nature Biotechnology (2020)