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  1. No Access

    Article

    The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease

    To characterize the dysregulation of chromatin accessibility in Alzheimer’s disease (AD), we generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the superior temporal gyrus and ...

    Jaroslav Bendl, Mads E. Hauberg, Kiran Girdhar, Eunju Im… in Nature Neuroscience (2022)

  2. Article

    Open Access

    Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

    Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgeni...

    Ju-Hyun Lee, Dun-Sheng Yang, Chris N. Goulbourne, Eunju Im… in Nature Neuroscience (2022)

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