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  1. Article

    Open Access

    Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

    NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here ...

    Eunee Lee, Seungjoon Lee, Jae ** Shin, Woochul Choi… in Nature Communications (2021)

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  2. No Access

    Article

    Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice

    Autism spectrum disorders (ASDs) are four times more common in males than in females, but the underlying mechanisms are poorly understood. We characterized sexually dimorphic changes in mice carrying a heteroz...

    Hwa** Jung, Haram Park, Yeonsoo Choi, Hyo** Kang, Eunee Lee… in Nature Neuroscience (2018)

  3. Article

    Open Access

    Left brain cortical activity modulates stress effects on social behavior

    When subjected to stress, some individuals develop maladaptive symptoms whereas others retain normal behavior. The medial prefrontal cortex (mPFC) is known to control these adaptive responses to stress. Here, ...

    Eunee Lee, Jiso Hong, Young-Gyun Park, Su** Chae, Yong Kim… in Scientific Reports (2015)

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  4. No Access

    Article

    Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

    Enhanced NMDA receptor function and social interaction deficits are observed in mice lacking the excitatory postsynaptic scaffolding protein IRSp53. Reducing NMDAR activity by pharmacological methods rescues t...

    Woosuk Chung, Su Yeon Choi, Eunee Lee, Haram Park, Jaeseung Kang… in Nature Neuroscience (2015)