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  1. No Access

    Article

    N-Adamantyl-4-Methylthiazol-2-Amine Attenuates Glutamate-Induced Oxidative Stress and Inflammation in the Brain

    In this study, we explored the possible mechanisms underlying the neuroprotective and anti-oxidative effects of N-adamantyl-4-methylthiazol-2-amine (KHG26693) against in vivo glutamate-induced toxicity in the rat...

    Seung-Ju Yang, Eun-A Kim, Min-Jun Chang, Jiae Kim, Jung-Min Na… in Neurotoxicity Research (2017)

  2. No Access

    Article

    2-Cyclopropylimino-3-methyl-1,3-thiazoline Hydrochloride Protects Against Beta-amyloid-induced Activation of the Apoptotic Cascade in Cultured Cortical Neurons

    Aggregated β-amyloid, implicated in the pathogenesis of Alzheimer’s disease (AD), induces neurotoxicity by evoking a cascade of oxidative damage-dependent apoptosis in neurons. We investigated the molecular me...

    Eun-A Kim, Chang Hun Cho, Hoh-Gyu Hahn… in Cellular and Molecular Neurobiology (2014)

  3. No Access

    Article

    Neuroprotective Effects of 2-Cyclopropylimino-3-Methyl-1,3-Thiazoline Hydrochloride Against Oxidative Stress

    Oxidative stress, glutamate excitotoxicity, and inflammation are the important pathological mechanisms in neurodegenerative diseases. Recently, we reported that 2-cyclopropylimino-3-methyl-1,3-thiazoline hydro...

    Hanwook Kim, Hyo Jeong Son, Seung Cheol Ha… in Cellular and Molecular Neurobiology (2011)

  4. No Access

    Article

    Suppression of Glutamate-Induced Excitotoxicity by 2-Cyclopropylimino-3-methyl-1,3-thiazoline Hydrochloride in Rat Glial Cultures

    We have screened new drugs with a view to develo** effective drugs against glutamate-induced excitotoxicity. In the present work, we show effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hyd...

    Eun-A Kim, Hoh-Gyu Hahn, Key-Sun Kim, Tae Ue Kim… in Cellular and Molecular Neurobiology (2010)