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  1. No Access

    Article

    Risk assessment of genetically modified zoysiagrasses (Zoysia japonica) in a zebrafish model

    Genetically modified (GM) plants have been mainly advanced for the mass production of agricultural plants. However, there are concerns about GM crops which cause side effects on ecosystems and human beings. Ze...

    Hye-Won Yang, Eun-A. Kim, Hyeon-** Sun, Hong-Gyu Kang… in Plant Biotechnology Reports (2021)

  2. No Access

    Article

    Neuroprotective Effect of 3-(Naphthalen-2-Yl(Propoxy)Methyl)Azetidine Hydrochloride on Brain Ischaemia/Reperfusion Injury

    Because ischaemic stroke is one of the most common brain disorders, diverse effective therapies are urgently required. Recent studies reported a variety of azetidine-based scaffolds for the development of cent...

    Eun-A Kim, Jung-Min Na, Jiae Kim, Soo Young Choi… in Journal of Neuroimmune Pharmacology (2017)

  3. No Access

    Article

    N-Adamantyl-4-Methylthiazol-2-Amine Attenuates Glutamate-Induced Oxidative Stress and Inflammation in the Brain

    In this study, we explored the possible mechanisms underlying the neuroprotective and anti-oxidative effects of N-adamantyl-4-methylthiazol-2-amine (KHG26693) against in vivo glutamate-induced toxicity in the rat...

    Seung-Ju Yang, Eun-A Kim, Min-Jun Chang, Jiae Kim, Jung-Min Na… in Neurotoxicity Research (2017)

  4. No Access

    Article

    2-Cyclopropylimino-3-methyl-1,3-thiazoline Hydrochloride Protects Against Beta-amyloid-induced Activation of the Apoptotic Cascade in Cultured Cortical Neurons

    Aggregated β-amyloid, implicated in the pathogenesis of Alzheimer’s disease (AD), induces neurotoxicity by evoking a cascade of oxidative damage-dependent apoptosis in neurons. We investigated the molecular me...

    Eun-A Kim, Chang Hun Cho, Hoh-Gyu Hahn… in Cellular and Molecular Neurobiology (2014)

  5. No Access

    Article

    2-Cyclopropylimino-3-Methyl-1,3-Thiazoline Hydrochloride Inhibits Microglial Activation by Suppression of Nuclear Factor-Kappa B and Mitogen-Activated Protein Kinase Signaling

    The activation of microglia is crucially associated with the neurodegeneration observed in many neuroinflammatory pathologies, including multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. Theref...

    Eun-A Kim, Jiyoung Choi, A. Reum Han, Chang Hun Cho… in Journal of Neuroimmune Pharmacology (2014)

  6. No Access

    Article

    Neuroprotective Effects of 2-Cyclopropylimino-3-Methyl-1,3-Thiazoline Hydrochloride Against Oxidative Stress

    Oxidative stress, glutamate excitotoxicity, and inflammation are the important pathological mechanisms in neurodegenerative diseases. Recently, we reported that 2-cyclopropylimino-3-methyl-1,3-thiazoline hydro...

    Hanwook Kim, Hyo Jeong Son, Seung Cheol Ha… in Cellular and Molecular Neurobiology (2011)

  7. No Access

    Article

    Suppression of Glutamate-Induced Excitotoxicity by 2-Cyclopropylimino-3-methyl-1,3-thiazoline Hydrochloride in Rat Glial Cultures

    We have screened new drugs with a view to develo** effective drugs against glutamate-induced excitotoxicity. In the present work, we show effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hyd...

    Eun-A Kim, Hoh-Gyu Hahn, Key-Sun Kim, Tae Ue Kim… in Cellular and Molecular Neurobiology (2010)

  8. No Access

    Article

    Suppression of lipopolysaccharide-induced microglial activation by a benzothiazole derivative

    We previously reported that KHG21834, a benzothiazole derivative, attenuates the beta-amyloid (Aβ)-induced degeneration of both cortical and mesencephalic neurons in vitro. Central nervous system inflammation med...

    Eun-A Kim, Hanwook Kim, Jee-Yin Ahn, Hoh-Gyu Hahn, Key-Sun Kim… in Molecules and Cells (2010)