-
Article
A general condition for spontaneous capillary flow in uniform cross-section microchannels
Spontaneous capillary flow (SCF) is a powerful method for moving fluids at the microscale. In modern biotechnology, composite channels—sometimes open—are increasingly used. The ability to predict the occurrenc...
-
Article
Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D
Directed neutrophil migration in blood vessels and tissues is critical for proper immune function; however, the mechanisms that regulate three-dimensional neutrophil chemotaxis remain unclear. It has been show...
-
Article
Open AccessMicrobial metabolomics in open microscale platforms
The microbial secondary metabolome encompasses great synthetic diversity, empowering microbes to tune their chemical responses to changing microenvironments. Traditional metabolomics methods are ill-equipped t...
-
Article
Open AccessMicrobial volatile communication in human organotypic lung models
We inhale respiratory pathogens continuously, and the subsequent signaling events between host and microbe are complex, ultimately resulting in clearance of the microbe, stable colonization of the host, or act...
-
Article
Stable biphasic interfaces for open microfluidic platforms
We present an open microfluidic platform that enables stable flow of an organic solvent over an aqueous solution. The device features apertures connecting a lower aqueous channel to an upper solvent compartmen...
-
Article
Open AccessUser-defined morphogen patterning for directing human cell fate stratification
Concentration gradients of biochemical stimuli such as morphogens play a critical role in directing cell fate patterning across species and throughout development but are not commonly recapitulated in vitro. Whil...
-
Article
Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling
The study of intercellular signalling networks requires organotypic microscale systems that facilitate the culture, conditioning and manipulation of cells. Here, we describe a reconfigurable microfluidic cell-...
-
Article
Open AccessFungal oxylipins direct programmed developmental switches in filamentous fungi
Filamentous fungi differentiate along complex developmental programs directed by abiotic and biotic signals. Currently, intrinsic signals that govern fungal development remain largely unknown. Here we show tha...
-
Article
Miniaturizing chemistry and biology using droplets in open systems
Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in an open environment. They combine the compartmentalization and control offered by traditional droplet-based microfl...
-
Article
Open AccessPoint-of-care BCR::ABL1 transcript monitoring using capillary dried blood in chronic myeloid leukemia patients
