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  1. No Access

    Article

    Discovery of a structural class of antibiotics with explainable deep learning

    The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis1–9. Deep learning approaches have aided in exploring chemical spaces1,10–15; these t...

    Felix Wong, Erica J. Zheng, Jacqueline A. Valeri, Nina M. Donghia… in Nature (2024)

  2. Article

    Open Access

    Modulating the evolutionary trajectory of tolerance using antibiotics with different metabolic dependencies

    Antibiotic tolerance, or the ability of bacteria to survive antibiotic treatment in the absence of genetic resistance, has been linked to chronic and recurrent infections. Tolerant cells are often characterize...

    Erica J. Zheng, Ian W. Andrews, Alexandra T. Grote… in Nature Communications (2022)

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