13 Result(s)
within
Eric Y. Chuang
Life Sciences
English
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Article
Open AccessIdentification of reproducible gene expression signatures in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related death worldwide. Tremendous research efforts have been devoted to improving treatment procedures, but the average five-year overall survival rates are still l...
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Article
Open AccessParameter optimization for constructing competing endogenous RNA regulatory network in glioblastoma multiforme and other cancers
In addition to direct targeting and repressing mRNAs, recent studies reported that microRNAs (miRNAs) can bridge up an alternative layer of post-transcriptional gene regulatory networks. The competing endogeno...
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Article
Open AccessCo-modulation analysis of gene regulation in breast cancer reveals complex interplay between ESR1 and ERBB2 genes
Gene regulation is dynamic across cellular conditions and disease subtypes. From the aspect of regulation under modulation, regulation strength between a pair of genes can be modulated by (dependent on) expres...
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Article
Open AccessA simple gene set-based method accurately predicts the synergy of drug pairs
The advance in targeted therapy has greatly increased the effectiveness of clinical cancer therapy and reduced the cytotoxicity of treatments to normal cells. However, patients still suffer from cancer relapse...
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Article
Open AccessiGC—an integrated analysis package of gene expression and copy number alteration
With the advancement in high-throughput technologies, researchers can simultaneously investigate gene expression and copy number alteration (CNA) data from individual patients at a lower cost. Traditional anal...
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Article
Open AccessDifferential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival
Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve coexpression by competing for a pool of common targeting miRNAs. ...
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Article
Open AccessGenome-wide identification of key modulators of gene-gene interaction networks in breast cancer
With the advances in high-throughput gene profiling technologies, a large volume of gene interaction maps has been constructed. A higher-level layer of gene-gene interaction, namely modulate gene interaction, ...
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Article
Open AccessanamiR: integrated analysis of MicroRNA and gene expression profiling
With advancements in high-throughput technologies, the cost of obtaining expression profiles of both mRNA and microRNA in the same individual has substantially decreased. Integrated analysis of these profiles ...
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Open AccessDifferential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population
Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here...
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Article
Open AccessRegulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells
Hypoxia is a classic feature of the tumor microenvironment that has profound effects on cancer progression and is tightly associated with poor prognosis. Long noncoding RNAs (lncRNAs), a component of the nonco...
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Article
Open AccessCLIN_SKAT: an R package to conduct association analysis using functionally relevant variants
Availability of next generation sequencing data, allows low-frequency and rare variants to be studied through strategies other than the commonly used genome-wide association studies (GWAS). Rare variants are i...
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Article
Open AccessTwnbiome: a public database of the healthy Taiwanese gut microbiome
With new advances in next generation sequencing (NGS) technology at reduced costs, research on bacterial genomes in the environment has become affordable. Compared to traditional methods, NGS provides high-thr...
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Article
Utilizing multimodal approach to identify candidate pathways and biomarkers and predicting frailty syndrome in individuals from UK Biobank
Frailty, a prevalent clinical syndrome in aging adults, is characterized by poor health outcomes, represented via a standardized frailty-phenotype (FP), and Frailty Index (FI). While the relevance of the syndr...
