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Article
Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood
Perseverative negative thoughts, known as rumination, might arise from emotional challenges and preclude mental health when transitioning into adulthood. Due to its multifaceted nature, rumination can take sev...
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Article
Open AccessLight Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing
For decades, cannabis has been the most widely used illicit substance in the world, particularly among youth. Research suggests that mental health problems associated with cannabis use may result from its effe...
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Article
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Despite its crucial role in the regulation of vital metabolic and neurological functions, the genetic architecture of the hypothalamus remains unknown. Here we conducted multivariate genome-wide association st...
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Article
Correction: Arc controls alcohol cue relapse by a central amygdala mechanism
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Article
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits
The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here ...
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Article
Open AccessWhole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood
A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these t...
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Article
Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior
Leveraging ~10 years of prospective longitudinal data on 704 participants, we examined the effects of adolescent versus young adult cannabis initiation on MRI-assessed cortical thickness development and behavi...
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Article
Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits
Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental proce...
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Article
Open AccessTrans-ancestry meta-analysis of genome wide association studies of inhibitory control
Deficits in effective executive function, including inhibitory control are associated with risk for a number of psychiatric disorders and significantly impact everyday functioning. These complex traits have be...
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Article
Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability
The temporo-basal region of the human brain is composed of the collateral, the occipito-temporal, and the rhinal sulci. We manually rated (using a novel protocol) the connections between rhinal/collateral (RS-...
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Article
Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains
With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neurom...
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Article
Arc controls alcohol cue relapse by a central amygdala mechanism
Alcohol use disorder (AUD) is a chronic and fatal disease. The main impediment of the AUD therapy is a high probability of relapse to alcohol abuse even after prolonged abstinence. The molecular mechanisms of ...
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Article
Open AccessAnxiety onset in adolescents: a machine-learning prediction
Recent longitudinal studies in youth have reported MRI correlates of prospective anxiety symptoms during adolescence, a vulnerable period for the onset of anxiety disorders. However, their predictive value has...
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Article
Cortical profiles of numerous psychiatric disorders and normal development share a common pattern
The neurobiological bases of the association between development and psychopathology remain poorly understood. Here, we identify a shared spatial pattern of cortical thickness (CT) in normative development and...
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Article
A causal association of ANKRD37 with human hippocampal volume
Human hippocampal volume has been separately associated with single nucleotide polymorphisms (SNPs), DNA methylation and gene expression, but their causal relationships remain largely unknown. Here, we aimed a...
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Article
Open AccessOrbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect
Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associatio...
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Article
Open AccessBayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning
While there is substantial evidence that cannabis use is associated with differences in human brain development, most of this evidence is correlational in nature. Bayesian causal network (BCN) modeling attempt...
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Article
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we id...
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Article
Global urbanicity is associated with brain and behaviour in young people
Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people...
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Article
Examination of the association between exposure to childhood maltreatment and brain structure in young adults: a machine learning analysis
Exposure to maltreatment during childhood is associated with structural changes throughout the brain. However, the structural differences that are most strongly associated with maltreatment remain unclear give...
