5 Result(s)
-
Article
A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics
Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin-stained tumor slides for precision oncology. We present ENLIGHT–DeepPT, an indirect two-step approach consisting of (...
-
Article
Open AccessThe stem rust fungus Puccinia graminis f. sp. tritici induces centromeric small RNAs during late infection that are associated with genome-wide DNA methylation
Silencing of transposable elements (TEs) is essential for maintaining genome stability. Plants use small RNAs (sRNAs) to direct DNA methylation to TEs (RNA-directed DNA methylation; RdDM). Similar mechanisms o...
-
Article
Predictor performance with stratified data and imbalanced classes
-
Article
Open AccessIdentification of RNA binding motif proteins essential for cardiovascular development
We recently identified Rbm24 as a novel gene expressed during mouse cardiac development. Due to its tightly restricted and persistent expression from formation of the cardiac crescent onwards and later in forming...
-
Article
Open AccessThe non-random clustering of non-synonymous substitutions and its relationship to evolutionary rate
Protein sequences are subject to a mosaic of constraint. Changes to functional domains and buried residues, for example, are more apt to disrupt protein structure and function than are changes to residues part...
