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Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis

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  1. Article

    Open Access

    DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

    Fanconi anemia (FA) is a multigenic disease of bone marrow failure and cancer susceptibility stemming from a failure to remove DNA crosslinks and other chromosomal lesions. Within the FA DNA damage response pa...

    Fengshan Liang, Adam S. Miller, Simonne Longerich, Caroline Tang… in Nature Communications (2019)

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  2. Article

    Open Access

    The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

    The transition of hematopoiesis from the fetal liver (FL) to the bone marrow (BM) is incompletely characterized. We demonstrate that the Wiskott–Aldrich syndrome verprolin-homologous protein (WAVE) complex 2 i...

    Lijian Shao, Jianhui Chang, Wei Feng, **aoyan Wang… in Nature Communications (2018)

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    Open Access

    Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

    Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have so...

    Gayathri Srinivasan, Gurjit Singh Sidhu… in Cancer Chemotherapy and Pharmacology (2017)

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  4. Article

    Open Access

    The DNA repair component Metnase regulates Chk1 stability

    Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...

    Elizabeth A Williamson, Yuehan Wu, Sudha Singh, Michael Byrne, Justin Wray… in Cell Division (2014)

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