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  1. Article

    Open Access

    Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice

    Obesity is associated with local tissue hypoxia and elevated hypoxia-inducible factor 1 alpha (HIF-1α) in metabolic tissues. Prolyl hydroxylases (PHDs) play an important role in regulating HIF-α isoform stabil...

    Amandine Thomas, Elise Belaidi, Judith Aron-Wisnewsky in Scientific Reports (2016)