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Article

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

Overexpression of recombinant proteins in bacteria may lead to their aggregation and deposition in inclusion bodies. Since the conformational properties of proteins in inclusion bodies exhibit many of the char...

Kalyani Sanagavarapu, Elisabeth Nüske, Irem Nasir, Georg Meisl… in Scientific Reports (2019)