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Article
Open AccessAnnexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein found within ribonucleoprotein granules tethered to lysosomes via annexin A11. TDP-43 protein forms inclusions in many neurodegenerative diseases i...
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Article
Open AccessPostmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer’s disease
Our current understanding of the spread and neurodegenerative effects of tau neurofibrillary tangles (NFTs) within the medial temporal lobe (MTL) during the early stages of Alzheimer’s Disease (AD) is limited ...
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Article
Open AccessUltrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling
Ultrastructure of human brain tissue has traditionally been examined using electron microscopy (EM) following fixation, staining, and sectioning, which limit resolution and introduce artifacts. Alternatively, ...
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Article
Open AccessMSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include Alzheimer’s disease (AD). The spreading...
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Article
Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology
Spatial transcriptomics (ST) has demonstrated enormous potential for generating intricate molecular maps of cells within tissues. Here we present iStar, a method based on hierarchical image feature extraction ...
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Article
Open AccessRisk of chronic traumatic encephalopathy in rugby union is associated with length of playing career
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Article
Open AccessThe neuropathology of intimate partner violence
Lifelong brain health consequences of traumatic brain injury (TBI) include the risk of neurodegenerative disease. Up to one-third of women experience intimate partner violence (IPV) in their lifetime, often wi...
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Article
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2
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Article
Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease
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Article
Open AccessHuman Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain’s major cell types and are responsible for maintaining neuronal homeostasis via regulating the extracellular environment, providing metabolic support, and modulating synaptic ac...
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Article
Open AccessLeveraging spatial transcriptomics data to recover cell locations in single-cell RNA-seq with CeLEry
Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular heterogeneity in health and disease. However, the lack of physical relationships among dissociated cells has limited its ...
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Article
Open AccessThe perils of contact sport: pathologies of diffuse brain swelling and chronic traumatic encephalopathy neuropathologic change in a 23-year-old rugby union player
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Article
Open AccessCorrection to: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
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Article
Open AccessSpaDecon: cell-type deconvolution in spatial transcriptomics with semi-supervised learning
Spatially resolved transcriptomics (SRT) has advanced our understanding of the spatial patterns of gene expression, but the lack of single-cell resolution in spatial barcoding-based SRT hinders the inference o...
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Article
Open AccessLATE-NC staging in routine neuropathologic diagnosis: an update
An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging s...
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Chapter and Conference Paper
Improved Segmentation of Deep Sulci in Cortical Gray Matter Using a Deep Learning Framework Incorporating Laplace’s Equation
When develo** tools for automated cortical segmentation, the ability to produce topologically correct segmentations is important in order to compute geometrically valid morphometry measures. In practice, acc...
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Article
The continuing legacy of John
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Article
Open AccessIsoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
Frontotemporal lobar degeneration with MAPT pathogenic variants (FTLD-MAPT) has heterogeneous tau pathological inclusions postmortem, consisting of three-repeat (3R) or four-repeat (4R) tau isoforms, or a combina...
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Article
TREM2 risk variants are associated with atypical Alzheimer’s disease
Alzheimer’s disease (AD) has multiple clinically and pathologically defined subtypes where the underlying causes of such heterogeneity are not well established. Rare TREM2 variants confer significantly increased ...
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Article
Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer’s disease
Alzheimer’s disease neuropathologic change (ADNC) is clinically heterogenous and can present with a classic multidomain amnestic syndrome or focal non-amnestic syndromes. Here, we investigated the distribution...
