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  1. Article

    Open Access

    Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

    Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 ac...

    S Gerboth, E Frittoli, A Palamidessi, F C Baltanas, M Salek, J Rappsilber… in Leukemia (2018)

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  2. No Access

    Article

    Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs

    Using a 4-hydroxytamoxifen (4OHT)-inducible, conditional Sos1-null mutation, we analyzed wild-type (WT), single Sos1-KO, Sos2-KO and double Sos1/2 KO primary mouse embryonic fibroblasts (MEF) with an aim at ev...

    P Liceras-Boillos, R García-Navas, A Ginel-Picardo, B Anta, M Pérez-Andrés… in Oncogene (2016)

  3. No Access

    Article

    Extracorporeal photopheresis in addition to pentostatin in conditioning for canine hematopoietic cell transplantation: role in engraftment

    Extracorporeal photopheresis (ECP) and the purine analog pentostatin exert potent immunomodulatory effects, but have not been evaluated for their ability to enhance engraftment of hematopoietic stem cells. We ...

    W A Bethge, F R Kerbauy, E Santos, T A Gooley, R Storb… in Bone Marrow Transplantation (2011)

  4. No Access

    Article

    Neuromonitoring

    Die Dynamik verschiedener spezifischer Parameter, wie z. B. des intrakraniellen Drucks, der zerebralen Oxygenierung und der zerebralen Perfusion, ist von entscheidender Bedeutung für die Prognose bei Patienten...

    Dr. D. Staykov, E. Santos, O.W. Sakowitz in Intensivmedizin und Notfallmedizin (2010)

  5. No Access

    Article

    Transcriptional networks of knockout cell lines identify functional specificities of H-Ras and N-Ras: significant involvement of N-Ras in biotic and defense responses

    We characterized differential gene expression profiles of fibroblast cell lines harboring single or double-homozygous null mutations in H-ras and N-ras. Whereas the expression level of the individual H-, N- and K...

    E Castellano, J De Las Rivas, C Guerrero, E Santos in Oncogene (2007)

  6. No Access

    Article

    Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant

    There are few reports describing the association between antiphospholipid antibodies, including the lupus anticoagulant, and bone marrow or peripheral stem cell transplantation. Autoimmune syndromes and autoan...

    M A Kharfan-Dabaja, D Morgensztern, E Santos, M Goodman… in Bone Marrow Transplantation (2003)

  7. No Access

    Article

    Transformation suppressor activity of C3G is independent of its CDC25-homology domain

    The guanine nucleotide releasing protein C3G was initially identified as a Crk SH3-binding protein and recently shown to exhibit exchange activity on Rap1 proteins. Overexpression in NIH3T3 cells of a full-len...

    C Guerrero, A Fernandez-Medarde, JM Rojas, J Font de Mora, LM Esteban, E Santos in Oncogene (1998)