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  1. Article

    Open Access

    Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

    Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 ac...

    S Gerboth, E Frittoli, A Palamidessi, F C Baltanas, M Salek, J Rappsilber in Leukemia (2018)

  2. No Access

    Article

    Standards of reporting: the use of CONSORT PRO and CERT in individuals living with osteoporosis

    The Consolidated Standards of Reporting Trials for Patient-Reported Outcomes (CONSORT PRO) and the Consensus on Exercise Reporting Template (CERT) have been developed to improve the quality and transparency of...

    D. E. Mack, P. M. Wilson, E. Santos, K. Brooks in Osteoporosis International (2018)

  3. No Access

    Article

    Hepatic Arterial Embolization Using Cone Beam CT with Tumor Feeding Vessel Detection Software: Impact on Hepatocellular Carcinoma Response

    Dedicated tumor feeding vessel detection software (TFVDS) using cone beam CT has shown a higher sensitivity to detect tumor feeding vessels during hepatic arterial embolization (HAE) of hepatocellular carcinom...

    F. H. Cornelis, A. Borgheresi, E. N. Petre in CardioVascular and Interventional Radiology (2018)

  4. No Access

    Article

    Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs

    Using a 4-hydroxytamoxifen (4OHT)-inducible, conditional Sos1-null mutation, we analyzed wild-type (WT), single Sos1-KO, Sos2-KO and double Sos1/2 KO primary mouse embryonic fibroblasts (MEF) with an aim at ev...

    P Liceras-Boillos, R García-Navas, A Ginel-Picardo, B Anta, M Pérez-Andrés in Oncogene (2016)

  5. No Access

    Article

    Transnodal Lymphangiography in the Diagnosis and Treatment of Genital Lymphedema

    To report the success of groin nodal lymphography in the diagnosis and treatment of genital lymphedema.

    F. M. Gómez, J. Martínez-Rodrigo in CardioVascular and Interventional Radiology (2012)

  6. No Access

    Article

    Extracorporeal photopheresis in addition to pentostatin in conditioning for canine hematopoietic cell transplantation: role in engraftment

    Extracorporeal photopheresis (ECP) and the purine analog pentostatin exert potent immunomodulatory effects, but have not been evaluated for their ability to enhance engraftment of hematopoietic stem cells. We ...

    W A Bethge, F R Kerbauy, E Santos, T A Gooley, R Storb in Bone Marrow Transplantation (2011)

  7. No Access

    Chapter and Conference Paper

    Cerebral Microdialysis in Acutely Brain-Injured Patients with Spreading Depolarizations

    Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. ...

    K. L. Krajewski, B. Orakcioglu, D. Haux in Early Brain Injury or Cerebral Vasospasm (2011)

  8. No Access

    Chapter

    Multiparametric Characterisation of the Perihemorrhagic Zone in a Porcine Model of Lobar ICH

    Objectives: To describe early perihemorrhagic changes after lobar intracerebral hemorrhage (ICH) using multiparametric neuromonitoring [intracranial pressure (ICP), cerebral blood flow (CBF), tis...

    Berk Orakcioglu, M. Kentar, Y. Uozumi, E. Santos in Intracerebral Hemorrhage Research (2011)

  9. Article

    Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in macular oedema with branch retinal vein occlusion

    To investigate whether interleukine-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are related with macular oedema in patients with branch retinal vein occlusions (BRVOs).

    A Fonollosa, J Garcia-Arumi, E Santos, C Macia, P Fernandez, R M Segura, M A Zapata in Eye (2010)

  10. No Access

    Article

    Neuromonitoring

    Die Dynamik verschiedener spezifischer Parameter, wie z. B. des intrakraniellen Drucks, der zerebralen Oxygenierung und der zerebralen Perfusion, ist von entscheidender Bedeutung für die Prognose bei Patienten...

    Dr. D. Staykov, E. Santos, O.W. Sakowitz in Intensivmedizin und Notfallmedizin (2010)

  11. Article

    Decisions to limit care: evaluation of newly graduated physicians during a selection process for medical residency in Brazil

    R Goldwasser, C David, A Coelho, E Muxfeldt, E Santos, V Fonseca, M Lobo in Critical Care (2008)

  12. No Access

    Article

    Behçet’s disease and Chiari’s network

    Behçet’s disease (BD) is a chronic, multisystemic, inflammatory process of uncertain origin. Diagnosis criteria consist of recurrent oral ulceration plus two of the following: genital ulceration, ocular and sk...

    G. Alonso, E. Santos, A. Fuertes, A. Jiménez, J. A. Gutiérrez in Clinical Rheumatology (2007)

  13. No Access

    Article

    Transcriptional networks of knockout cell lines identify functional specificities of H-Ras and N-Ras: significant involvement of N-Ras in biotic and defense responses

    We characterized differential gene expression profiles of fibroblast cell lines harboring single or double-homozygous null mutations in H-ras and N-ras. Whereas the expression level of the individual H-, N- and K...

    E Castellano, J De Las Rivas, C Guerrero, E Santos in Oncogene (2007)

  14. No Access

    Article

    Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant

    There are few reports describing the association between antiphospholipid antibodies, including the lupus anticoagulant, and bone marrow or peripheral stem cell transplantation. Autoimmune syndromes and autoan...

    M A Kharfan-Dabaja, D Morgensztern, E Santos, M Goodman in Bone Marrow Transplantation (2003)

  15. No Access

    Article

    Arteriovenous fistula as a complication of lumbar disc surgery: case report

    Arteriovenous fistula (AVF) is a rare, late complication of lumbar disc surgery. It is often not suspected and the symptoms are diagnosed as heart failure or deep venous thrombosis. We report a case in which ...

    E. Santos, V. Peral, M. Aroca, A. Hernández Lezana, F. J. Serrano in Neuroradiology (1998)

  16. No Access

    Article

    Transformation suppressor activity of C3G is independent of its CDC25-homology domain

    The guanine nucleotide releasing protein C3G was initially identified as a Crk SH3-binding protein and recently shown to exhibit exchange activity on Rap1 proteins. Overexpression in NIH3T3 cells of a full-len...

    C Guerrero, A Fernandez-Medarde, JM Rojas, J Font de Mora, LM Esteban, E Santos in Oncogene (1998)

  17. No Access

    Article

    Abstracts

    M. Gawdziński, J. Sypuła, J. Źochowski in The International Journal of Cardiac Imagi… (1989)

  18. No Access

    Article

    Late osteoarticular lesions following meningococcemia with disseminated intravascular coagulation

    Nineteen children, who had been admitted to the Pediatric Hospital of Coimbra with severe meningococcal infection with DIC, were submitted to clinical and radiological examination, an average of 4.2 years afte...

    E. Santos, J. E. Boavida, A. Barroso, J. Seabra, H. Carmona da Mota in Pediatric Radiology (1989)