![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessPhosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis
Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 ac...
-
Article
Standards of reporting: the use of CONSORT PRO and CERT in individuals living with osteoporosis
The Consolidated Standards of Reporting Trials for Patient-Reported Outcomes (CONSORT PRO) and the Consensus on Exercise Reporting Template (CERT) have been developed to improve the quality and transparency of...
-
Article
Hepatic Arterial Embolization Using Cone Beam CT with Tumor Feeding Vessel Detection Software: Impact on Hepatocellular Carcinoma Response
Dedicated tumor feeding vessel detection software (TFVDS) using cone beam CT has shown a higher sensitivity to detect tumor feeding vessels during hepatic arterial embolization (HAE) of hepatocellular carcinom...
-
Article
Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs
Using a 4-hydroxytamoxifen (4OHT)-inducible, conditional Sos1-null mutation, we analyzed wild-type (WT), single Sos1-KO, Sos2-KO and double Sos1/2 KO primary mouse embryonic fibroblasts (MEF) with an aim at ev...
-
Article
Transnodal Lymphangiography in the Diagnosis and Treatment of Genital Lymphedema
To report the success of groin nodal lymphography in the diagnosis and treatment of genital lymphedema.
-
Article
Extracorporeal photopheresis in addition to pentostatin in conditioning for canine hematopoietic cell transplantation: role in engraftment
Extracorporeal photopheresis (ECP) and the purine analog pentostatin exert potent immunomodulatory effects, but have not been evaluated for their ability to enhance engraftment of hematopoietic stem cells. We ...
-
Chapter and Conference Paper
Cerebral Microdialysis in Acutely Brain-Injured Patients with Spreading Depolarizations
Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. ...
-
Chapter
Multiparametric Characterisation of the Perihemorrhagic Zone in a Porcine Model of Lobar ICH
Objectives: To describe early perihemorrhagic changes after lobar intracerebral hemorrhage (ICH) using multiparametric neuromonitoring [intracranial pressure (ICP), cerebral blood flow (CBF), tis...
-
Article
Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in macular oedema with branch retinal vein occlusion
To investigate whether interleukine-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are related with macular oedema in patients with branch retinal vein occlusions (BRVOs).
-
Article
Neuromonitoring
Die Dynamik verschiedener spezifischer Parameter, wie z. B. des intrakraniellen Drucks, der zerebralen Oxygenierung und der zerebralen Perfusion, ist von entscheidender Bedeutung für die Prognose bei Patienten...
-
Article
Decisions to limit care: evaluation of newly graduated physicians during a selection process for medical residency in Brazil
-
Article
Behçet’s disease and Chiari’s network
Behçet’s disease (BD) is a chronic, multisystemic, inflammatory process of uncertain origin. Diagnosis criteria consist of recurrent oral ulceration plus two of the following: genital ulceration, ocular and sk...
-
Article
Transcriptional networks of knockout cell lines identify functional specificities of H-Ras and N-Ras: significant involvement of N-Ras in biotic and defense responses
We characterized differential gene expression profiles of fibroblast cell lines harboring single or double-homozygous null mutations in H-ras and N-ras. Whereas the expression level of the individual H-, N- and K...
-
Article
Acute graft-versus-host disease (aGVHD) presenting with an acquired lupus anticoagulant
There are few reports describing the association between antiphospholipid antibodies, including the lupus anticoagulant, and bone marrow or peripheral stem cell transplantation. Autoimmune syndromes and autoan...
-
Article
Arteriovenous fistula as a complication of lumbar disc surgery: case report
Arteriovenous fistula (AVF) is a rare, late complication of lumbar disc surgery. It is often not suspected and the symptoms are diagnosed as heart failure or deep venous thrombosis. We report a case in which ...
-
Article
Transformation suppressor activity of C3G is independent of its CDC25-homology domain
The guanine nucleotide releasing protein C3G was initially identified as a Crk SH3-binding protein and recently shown to exhibit exchange activity on Rap1 proteins. Overexpression in NIH3T3 cells of a full-len...
-
Article
Abstracts
-
Article
Late osteoarticular lesions following meningococcemia with disseminated intravascular coagulation
Nineteen children, who had been admitted to the Pediatric Hospital of Coimbra with severe meningococcal infection with DIC, were submitted to clinical and radiological examination, an average of 4.2 years afte...