-
Article
Open AccessPublisher Erratum: Production of antihydrogen atoms by 6 keV antiprotons through a positronium cloud
-
Article
Open AccessProduction of antihydrogen atoms by 6 keV antiprotons through a positronium cloud
We report on the first production of an antihydrogen beam by charge exchange of 6.1 keV antiprotons with a cloud of positronium in the GBAR experiment at CERN. The 100 keV antiproton beam delivered by the AD/E...
-
Article
Parallelization of Implementations of Purely Sequential Algorithms
The work is dedicated to the parallelization of programs in especially difficult cases when the used algorithm is purely sequential, there are no parallel alternatives to this algorithm, and its execution time...
-
Article
Atypicalities of Gesture Form and Function in Autistic Adults
While well-represented on clinical measures, co-speech gesture production has never been formally studied in autistic adults. Twenty-one verbally fluent autistic adults and 21 typically develo** controls eng...
-
Article
C-reactive protein binds to integrin α2 and Fcγ receptor I, leading to breast cell adhesion and breast cancer progression
C-reactive protein (CRP) is an acute phase protein synthesized upon the inflammatory responses, associated with breast cancer. The process of tumor cell invasion and metastasis involves the adherence of cells ...
-
Article
agr functionality affects clinical outcomes in patients with persistent methicillin-resistant Staphylococcus aureus bacteraemia
Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) often persists despite appropriate antibiotic therapy. It is unclear what microbiological factors contribute to poor clinical outcomes in persistent ...
-
Article
Phenotypic changes of methicillin-resistant Staphylococcus aureus during vancomycin therapy for persistent bacteraemia and related clinical outcome
Persistent bacteraemia (PB) due to methicillin-resistant Staphylococcus aureus (MRSA) that fails to respond to glycopeptide therapy is a well-documented clinical problem. There are limited data on changes in agr ...
-
Article
ITS1–5.8S rDNA–ITS2 sequence in 35S rRNA genes as marker for reconstruction of phylogeny of grasses (Poaceae family)
The problems associated with characteristics of the organization and evolution of the ITS1–5.8S rDNA–ITS2 region of 35S rRNA genes in the plant genome are discussed. It was demonstrated that phylogenetic hypot...
-
Article
Patiromer: A Review in Hyperkalaemia
Patiromer (Veltassa™) for oral suspension is a sodium-free potassium binder that is approved in the USA for the treatment of hyperkalaemia. In clinical trials, patiromer significantly reduced serum potassium leve...
-
Article
Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment
Goats and sheep are versatile domesticates that have been integrated into diverse environments and production systems. Natural and artificial selection have shaped the variation in the two species, but natural...
-
Article
Open AccessReactivation of p53 via MDM2 inhibition
-
Article
Open AccessThe MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma
Neuroblastoma is an aggressive pediatric malignancy which is >98% p53 wild-type at diagnosis. As a primary repressor of p53 activity and part of a p53-activated negative feedback loop, targeting of mouse doubl...
-
Article
Open AccessNSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis
Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to effectively...
-
Article
Gα12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial–mesenchymal transition of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has a poor prognosis owing to aggressive phenotype. Gα12 gep oncogene product couples to G-protein-coupled receptors, whose ligand levels are frequently increased in tumor microenvi...
-
Article
Prevalence of blaZ gene types and the cefazolin inoculum effect among methicillin-susceptible Staphylococcus aureus blood isolates and their association with multilocus sequence types and clinical outcome
Cefazolin treatment failures have been described for bacteraemia caused by methicillin-susceptible Staphylococcus aureus (MSSA) with type A β-lactamase and inoculum effect (InE). We investigated the prevalence of...
-
Article
Microwave dielectric properties of cordierite-diopside glass-ceramics
The dependence of microwave dielectric properties on the crystallization behavior of (1-x) Mg2Al4Si5O18 – xCaMgSi2O6 glass-ceramics was investigated as a function of the CaMgSi2O6 content (x) and heat-treatment t...
-
Article
Design of the RAON accelerator systems
The RAON is the name of the heavy ion accelerator facility under construction in Korea that includes the In-flight Fragment (IF) and Isotope Separation On-Line (ISOL) facilities to support cutting-edge researc...
-
Article
Levels of 4-1BB transcripts and soluble 4-1BB protein are elevated in the adipose tissue of human obese subjects and are associated with inflammatory and metabolic parameters
4-1BB, a member of the TNF receptor superfamily, has a role in various inflammatory pathologies through its interaction with 4-1BB ligand. We previously demonstrated that it participates in initiating and prom...
-
Article
Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression
A crucial role of the inflammatory lipid sphingosine-1-phosphate (S1P) in breast cancer aggressiveness has been reported. Recent clinical studies have suggested that C-reactive protein (CRP) has a role in brea...
-
Article
Open AccessA small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways
Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function is largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N),...
