10 Result(s)

Article

Reactivation of p53 via MDM2 inhibition

E S Kim, J M Shohet in Cell Death & Disease (2015)

Article

The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma

Neuroblastoma is an aggressive pediatric malignancy which is >98% p53 wild-type at diagnosis. As a primary repressor of p53 activity and part of a p53-activated negative feedback loop, targeting of mouse doubl...

A Lakoma, E Barbieri, S Agarwal, J Jackson, Z Chen, Y Kim, M McVay… in Cell Death Discovery (2015)

Article

NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis

Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to effectively...

Y Shi, I T Ma, R H Patel, X Shang, Z Chen, Y Zhao, J Cheng, Y Fan… in Cell Death & Disease (2015)

Article

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

Neuroblastoma (NB) is the most common extracranial neoplasm in children. In NB, loss of p53 function is largely due to cytoplasmic sequestration rather than mutation. Ubiquitin-conjugating enzyme E2 N (UBE2N),...

J Cheng, Y-H Fan, X Xu, H Zhang, J Dou, Y Tang, X Zhong, Y Rojas… in Cell Death & Disease (2014)

Article

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

Neuroblastoma (NB) is a common pediatric cancer and contributes to more than 15% of all pediatric cancer-related deaths. Unlike adult tumors, recurrent somatic mutations in NB, such as tumor protein 53 (p53) m...

Y-H Fan, J Cheng, S A Vasudevan, J Dou, H Zhang, R H Patel, I T Ma… in Cell Death & Disease (2013)