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  1. Article

    Open Access

    Targeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms

    With the intent of dissecting the molecular complexity of Philadelphia-negative myeloproliferative neoplasms (MPN), we designed a target enrichment panel to explore, using next-generation sequencing (NGS), the...

    E Tenedini, I Bernardis, V Artusi, L Artuso, E Roncaglia, P Guglielmelli… in Leukemia (2014)

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  2. Article

    Open Access

    Integrated analysis of microRNA and mRNA expression profiles in physiological myelopoiesis: role of hsa-mir-299-5p in CD34+ progenitor cells commitment

    Hematopoiesis entails a series of hierarchically organized events that proceed throughout cell specification and terminates with cell differentiation. Commitment needs the transcription factors' effort, which,...

    E Tenedini, E Roncaglia, F Ferrari, C Orlandi, E Bianchi… in Cell Death & Disease (2010)

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  3. No Access

    Article

    Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: focus on DNA repair genes

    Acute promyelocytic leukemia (APL) is a clonal expansion of hematopoietic precursors blocked at the promyelocytic stage. Gene expression profiles of APL cells obtained from 16 patients were compared to eight s...

    I Casorelli, E Tenedini, E Tagliafico, M F Blasi, A Giuliani, M Crescenzi… in Leukemia (2006)

  4. Article

    Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells

    Upregulation of specific transcription factors is a generally accepted mechanism to explain the commitment of hematopoietic stem cells along precise maturation lineages. Based on this premise, transduction of ...

    C Gemelli, M Montanari, E Tenedini, T Zanocco Marani… in Cell Death & Differentiation (2006)

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  5. No Access

    Article

    Identification of a molecular signature predictive of sensitivity to differentiation induction in acute myeloid leukemia

    Acute myeloid leukemia (AML) blasts are immature committed myeloid cells unable to spontaneously undergo terminal maturation, and characterized by heterogeneous sensitivity to natural differentiation inducers....

    E Tagliafico, E Tenedini, R Manfredini, A Grande, F Ferrari, E Roncaglia… in Leukemia (2006)

  6. Article

    Correlation between differentiation plasticity and mRNA expression profiling of CD34+-derived CD14− and CD14+ human normal myeloid precursors

    In spite of their apparently restricted differentiation potentiality, hematopoietic precursors are plastic cells able to trans-differentiate from a maturation lineage to another. To better characterize this di...

    M Montanari, C Gemelli, E Tenedini, T Zanocco Marani… in Cell Death & Differentiation (2005)

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  7. Article

    Gene expression profile of Vitamin D3 treated HL60 cells shows an incomplete molecular phenotypic conversion to monocytes

    By high density oligonucleotide microarrays we have studied the expression profile of proliferating and VD treated HL60 cells and the molecular phenotype of VD monocytes and that of CD14+ peripheral monocytes ...

    E Tagliafico, E Tenedini, A Bergamaschi, R Manfredini… in Cell Death & Differentiation (2002)

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