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Article
Open AccessTargeted cancer exome sequencing reveals recurrent mutations in myeloproliferative neoplasms
With the intent of dissecting the molecular complexity of Philadelphia-negative myeloproliferative neoplasms (MPN), we designed a target enrichment panel to explore, using next-generation sequencing (NGS), the...
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Article
Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: focus on DNA repair genes
Acute promyelocytic leukemia (APL) is a clonal expansion of hematopoietic precursors blocked at the promyelocytic stage. Gene expression profiles of APL cells obtained from 16 patients were compared to eight s...
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Article
Identification of a molecular signature predictive of sensitivity to differentiation induction in acute myeloid leukemia
Acute myeloid leukemia (AML) blasts are immature committed myeloid cells unable to spontaneously undergo terminal maturation, and characterized by heterogeneous sensitivity to natural differentiation inducers....