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  1. No Access

    Article

    Pomalidomide in myeloproliferative neoplasm-associated myelofibrosis

    Myeloproliferative neoplasm (MPN)-associated myelofibrosis is a MPN characterized by bone marrow fibrosis, cytopenias, splenomegaly and constitutional symptoms. Pomalidomide, an immune-modifying drug, is repor...

    R F Schlenk, F Stegelmann, A Reiter, E Jost, N Gattermann, H Hebart, C Waller… in Leukemia (2017)

  2. No Access

    Article

    Health care setting and severity, symptom burden, and complications in patients with Philadelphia-negative myeloproliferative neoplasms (MPN): a comparison between university hospitals, community hospitals, and office-based physicians

    Philadelphia-negative myeloproliferative neoplasms (MPN) comprise a heterogeneous group of chronic hematological malignancies with significant variations in clinical characteristics. Due to the long survival a...

    A. Kaifie, S. Isfort, N. Gattermann, W. Hollburg, M. Klausmann… in Annals of Hematology (2016)

  3. Article

    Open Access

    Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry

    Patients with Ph-negative myeloproliferative neoplasms (MPN), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are at increased risk for thrombosis/thromboemboli...

    A. Kaifie, M. Kirschner, D. Wolf, C. Maintz, M. Hänel… in Journal of Hematology & Oncology (2016)

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  4. Article

    Open Access

    Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia

    Mutations in the genetic sequence of the DNA de novo methyltransferase DNMT3A (DNA methyltransferase 3A) are found in many patients with acute myeloid leukemia (AML). They lead to dysfunction of DNMT3A protein an...

    E Jost, Q Lin, C I Weidner, S Wilop, M Hoffmann, T Walenda, M Schemionek… in Leukemia (2014)

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  5. No Access

    Article

    Hypercholesterolemia and its association with enhanced stem cell mobilization and harvest after high-dose cyclophosphamide+G-CSF

    High-dose chemotherapy with autologous peripheral blood SCT is a common treatment option in several hematological and non-hematological malignancies. So far, prediction of successful stem cell mobilization and...

    M Crysandt, R-D Hilgers, S von Hobe, A Eisert, E Jost… in Bone Marrow Transplantation (2011)

  6. No Access

    Article

    SOCS2: inhibitor of JAK2V617F-mediated signal transduction

    Janus kinase 2 (JAK2)V617F-activating mutations (JAK2mu) occur in myeloproliferative disorders (MPDs) and myelodysplastic syndromes (MDSs). Cell lines MB-02, MUTZ-8, SET-2 and UKE-1 carry JAK2V617F and derive fro...

    H Quentmeier, R Geffers, E Jost, R A F MacLeod, S Nagel, S Röhrs, J Romani… in Leukemia (2008)

  7. No Access

    Article

    Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders

    An acquired autoactivating mutation with a V617F amino-acid substitution in the JAK2 tyrosine kinase is frequently found in BCR/ABL-negative myeloproliferative disorders (MPD). Hypermethylation of CpG islands wit...

    E Jost, N do Ó, E Dahl, C E Maintz, P Jousten, L Habets, S Wilop, J G Herman… in Leukemia (2007)

  8. No Access

    Article

    DNA methylation changes in multiple myeloma

    Using a candidate gene approach, we analyzed the methylation status of the promoter-associated CpG islands of 11 well-characterized tumor suppressor genes by methylation-specific polymerase chain reaction in f...

    O Galm, S Wilop, J Reichelt, E Jost, G Gehbauer, J G Herman, R Osieka in Leukemia (2004)

  9. No Access

    Article

    Complex karyotype and absence of mutation in the c-kit receptor in aggressive mastocytosis presenting with pelvic osteolysis, eosinophilia and brain damage

    Aggressive mastocytosis is a form of systemic mast cell disease (SMCD) characterized by organ infiltration, bone lesions, eosinophilia and lymphadenopathies. Here we report a patient with unusual clinical fea...

    E. Jost, L. Michaux, M. Vanden Abeele, B. Boland, D. Latinne… in Annals of Hematology (2001)

  10. No Access

    Article

    Remission of severe cold agglutinin disease Rituximab therapy

    N Layios, E Van Den Neste, E Jost, V Deneys, JM Scheiff, A Ferrant in Leukemia (2001)