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within E Grassman Remove this filter Human Genetics Remove this filter

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  1. No Access

    Article

    Critical Variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency

    Patients with X-linked severe combined immunodeficiency (SCID-X1) were successfully cured following gene therapy with a gamma-retroviral vector (gRV) expressing the common gamma chain of the interleukin-2 rece...

    J C M van der Loo, W P Swaney, E Grassman, A Terwilliger, T Higashimoto… in Gene Therapy (2012)

  2. No Access

    Article

    Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection

    The need for γ-retroviral (gRV) vectors with a self-inactivating (SIN) design for clinical application has prompted a shift in methodology of vector manufacturing from the traditional use of stable producer li...

    J C M van der Loo, W P Swaney, E Grassman, A Terwilliger, T Higashimoto… in Gene Therapy (2012)