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Article
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway
Refractory wounds are a severe complication of diabetes mellitus that often leads to amputation because of the lack of effective treatments and therapeutic targets. The pathogenesis of refractory wounds is com...
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Article
Open AccessDe novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation
The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovar...
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Article
Open AccessRealization of monolayer ZrTe5 topological insulators with wide band gaps
Two-dimensional topological insulators hosting the quantum spin Hall effect have application potential in dissipationless electronics. To observe the quantum spin Hall effect at elevated temperatures, a wide b...
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Article
Open AccessLimit state equation and failure pressure prediction model of pipeline with complex loading
Assessing failure pressure is critical in determining pipeline integrity. Current research primarily concerns the buckling performance of pressurized pipelines subjected to a bending load or axial compression ...
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Article
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway
Cardiac fibrosis is a detrimental pathological process, which constitutes the key factor for adverse cardiac structural remodeling leading to heart failure and other critical conditions. Circular RNAs (circRNA...
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Article
Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice
The pathophysiology of autism spectrum disorders (ASDs) is causally linked to postsynaptic scaffolding proteins, as evidenced by numerous large-scale genomic studies [1, 2] and in vitro and in vivo neurobiologica...
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Article
Open AccessClinical characteristics and removal approaches of tracheal and bronchial foreign bodies in elders
The symptoms of tracheobronchial foreign body in the elderly are not typical, so they are often missed or misdiagnosed. This study aims to depict the clinical characteristics of tracheobronchial foreign body i...
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Article
Open AccessMetformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling
Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuro...
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Article
Cytogenetic analysis reveals a mechanism of compatibility in distant hybridization between tree peony and herbaceous peony
Cross-incompatibility is the major challenge in inter-sectional distant hybridization between tree peonies (Paeonia sect. Moutan) and herbaceous peonies (Paeonia sect. Paeonia). Most of the intersectional cross c...
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Article
Open AccessPMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness
Host survival depends on the elimination of virus and mitigation of tissue damage. Herein, we report the modulation of D-mannose flux rewires the virus-triggered immunometabolic response cascade and reduces ti...
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
New Metabolite from the Fungus Pseudopithomyces sp. J6
A new γ-lactone, namely pseudopithomyceslactone A (1), and three known compounds were isolated from the endophytic fungus Pseudopithomyces sp. J6. The structure of 1 was elucidated by extensive spectroscopic anal...
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Article
Impact of preoperative [18F]FDG PET/CT vs. contrast-enhanced CT in the staging and survival of patients with clinical stage I and II non-small cell lung cancer: a 10-year follow-up study
To elucidate the impact of [18F]FDG positron emission tomography/computed tomography (PET/CT) vs. CT workup on staging and prognostic evaluation of clinical stage (c) I-II NSCLC.
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Chapter and Conference Paper
Design of a Decision Support and Service System for Academic Big Data in Universities
Based on university academic big data, the design idea of a decision support and service system to meet the academic data needs in universities is studied. The method of integrating discrete, heterogeneous and...
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Chapter and Conference Paper
Experimental Investigation on the Pyrolysis Characteristics of Low-Medium Maturity Shale Under Supercritical CO2
Low-medium maturity organic-rich shale reservoirs have been widely concerned due to their huge reserves and oil and gas generation potential. In this study, the pyrolysis transformation process and product dis...
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Chapter and Conference Paper
Fracture Modeling and Connectivity Analysis in Northern Yueman, Fuman Oilfield, Tarim Basin
In view of the problems existing in the fracture reservoir modeling method for fine description of carbonate reservoir, the idea and method of fracture reservoir modeling based on DFN discrete fracture network...
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Article
Open AccessSRSF2 is required for mRNA splicing during spermatogenesis
RNA splicing plays significant roles in fundamental biological activities. However, our knowledge about the roles of alternative splicing and underlying mechanisms during spermatogenesis is limited.
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Article
The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence
Recent studies provide clues that astrocyte senescence is correlated with Parkinson’s disease (PD) progression, while little is known about the molecular basis for astrocyte senescence in PD. Here, we found th...
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Article
Research trends and hotspots of neoadjuvant therapy in pancreatic cancer: a bibliometric analysis based on the Web of Science Core Collection
Neoadjuvant therapy (NAT) for pancreatic cancer (PC) has achieved certain results. This article was aimed to analyze the trends in NAT in PC over the past 20 years using bibliometric analysis and visualization...
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Article
Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles
Hepatic stellate cell (HSC) activation is the central event in hepatic fibrosis. The cross-talk between HSCs and hepatocytes, which is mediated by extracellular vesicles (EVs), affects HSC activation. This stu...
