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Article
Open AccessWhole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals
Iron plays a fundamental role in multiple brain disorders. However, the genetic underpinnings of brain iron and its implications for these disorders are still lacking. Here, we conduct an exome-wide associatio...
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Article
Open AccessMeasurements of electroweak W±Z boson pair production in association with two jets in pp collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
Measurements of integrated and differential cross-sections for electroweak W±Z production in association with two jets (W±Zjj) in proton-proton collisions are presented. The data collected by the ATLAS detector a...
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Article
Open AccessLocalized, highly efficient secretion of signaling proteins by migrasomes
Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological ...
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Article
An universal in-situ phosphating strategy to fabricate high-performance Co2P-based bifunctional oxygen electrocatalyst derived from conjugated polyaniline-phytic acid copolymer
Electrocatalysts play a crucial role in the performance of rechargeable Zn-air batteries (ZABs), but it is still difficult to produce nonprecious materials with excellent bifunctional oxygen reduction reaction...
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Article
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D
Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores after cleavage by inflammatory ...
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Article
Open AccessPopulation genetic structure of Pomacea canaliculata in China based on the COI and ITS1 genes
Comprehending the phylogeography of invasive organisms enhances our insight into their distribution dynamics, which is instrumental for the development of effective prevention and management strategies. In Chi...
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Article
Open AccessSearch for new particles in final states with a boosted top quark and missing transverse momentum in proton-proton collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search for events with one top quark and missing transverse momentum in the final state is presented. The fully hadronic decay of the top quark is explored by selecting events with a reconstructed boosted to...
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Article
Open AccessSearch for electroweak production of supersymmetric particles in final states with two τ-leptons in \( \sqrt{s} \) = 13 TeV pp collisions with the ATLAS detector
Three searches for the direct production of τ-sleptons or charginos and neutralinos in final states with at least two hadronically decaying τ-leptons are presented. For chargino and neutralino production, decays ...
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Article
Open AccessTest of CP-invariance of the Higgs boson in vector-boson fusion production and in its decay into four leptons
A search for CP violation in the decay kinematics and vector-boson fusion production of the Higgs boson is performed in the H → ZZ* → 4ℓ (ℓ = e, μ) decay channel. The results are based on proton-proton collision ...
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Article
Open AccessATLAS Run 2 searches for electroweak production of supersymmetric particles interpreted within the pMSSM
A summary of the constraints from searches performed by the ATLAS collaboration for the electroweak production of charginos and neutralinos is presented. Results from eight separate ATLAS searches are consider...
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Article
Open AccessCRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations
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Article
Open AccessOTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death
Pancreatic cancer is one of the most fatal cancers in the world. A growing number of studies have begun to demonstrate that mitochondria play a key role in tumorigenesis. Our previous study reveals that NDUFS2 (N...
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Article
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator
SCH23390 is a widely used D1 dopamine receptor (D1R) antagonist that also elicits some D1R-independent effects. We previously found that the benzazepine, SKF83959, an analog of SCH23390, produces positive alloste...
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Article
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Despite its crucial role in the regulation of vital metabolic and neurological functions, the genetic architecture of the hypothalamus remains unknown. Here we conducted multivariate genome-wide association st...
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Article
Open AccessCell-free DNA methylation reveals cell-specific tissue injury and correlates with disease severity and patient outcomes in COVID-19
The recently identified methylation patterns specific to cell type allows the tracing of cell death dynamics at the cellular level in health and diseases. This study used COVID-19 as a disease model to investi...
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Article
Open AccessSearch for a CP-odd Higgs boson decaying into a heavy CP-even Higgs boson and a Z boson in the \( {\ell}^{+}{\ell}^{-}t\overline{t} \) and \( \nu \overline{\nu}b\overline{b} \) final states using 140 fb−1 of data collected with the ATLAS detector
A search for a heavy CP-odd Higgs boson, A, decaying into a Z boson and a heavy CP-even Higgs boson, H, is presented. It uses the full LHC Run 2 dataset of pp collisions at
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Article
Interactions between overweight/obesity and alcohol dependence impact human brain white matter microstructure: evidence from DTI
There is inconsistent evidence for an association of obesity with white matter microstructural alterations. Such inconsistent findings may be related to the cumulative effects of obesity and alcohol dependence...
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Article
Open AccessMeasurement of the production cross-section of \(J/\psi \) and \(\psi (2{\textrm{S}})\) mesons in pp collisions at \(\sqrt{s} = 13\) TeV with the ATLAS detector
Measurements of the differential production cross-sections of prompt and non-prompt \(J/\psi \) ...
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Article
Open AccessLNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing
Adipose stem cells (ASCs) have attracted considerable attention as potential therapeutic agents due to their ability to promote tissue regeneration. However, their limited tissue repair capability has posed a ...
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Article
Open AccessMeasurement of the \(H \rightarrow \gamma \gamma \) and \(H \rightarrow ZZ^* \rightarrow 4 \ell \) cross-sections in pp collisions at \(\sqrt{s}=13.6\) TeV with the ATLAS detector
The inclusive Higgs boson production cross-section is measured in the di-photon and the \(ZZ^* \rightarrow 4 \ell \) ...
