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Article
Open AccessArtificial intelligence-based graded training of pulmonary nodules for junior radiology residents and medical imaging students
To evaluate the efficiency of artificial intelligence (AI)-assisted diagnosis system in the pulmonary nodule detection and diagnosis training of junior radiology residents and medical imaging students.
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Article
Open AccessTargeting CXCR4/CXCL12 axis via [177Lu]Lu-DOTAGA.(SA.FAPi)2 with CXCR4 antagonist in triple-negative breast cancer
Radiopharmaceutical therapies targeting fibroblast activation protein (FAP) have shown promising efficacy against many tumor types. But radiopharmaceuticals alone in most cases are insufficient to completely e...
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Article
Open AccessDisruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis
Macrophage-orchestrated inflammation contributes to multiple diseases including sepsis. However, the underlying mechanisms remain to be defined clearly. Here, we show that macrophage TP53-induced glycolysis an...
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Open AccessLysosomal dysfunction and overload of nucleosides in thymidine phosphorylase deficiency of MNGIE
Inherited deficiency of thymidine phosphorylase (TP), encoded by TYMP, leads to a rare disease with multiple mitochondrial DNA (mtDNA) abnormalities, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)....
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Open AccessCorrelation of meniscus tear type with synovial inflammation and the therapeutic potential of docosapentaenoic acid
Synovitis, characterized by inflammation of the synovial membrane, is commonly induced by meniscus tears. However, significant differences in inflammatory responses and the key inflammatory mediators of synovi...
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Article
Open AccessThe formation of unsaturated IrOx in SrIrO3 by cobalt-do** for acidic oxygen evolution reaction
Electrocatalytic water splitting is a promising route for sustainable hydrogen production. However, the high overpotential of the anodic oxygen evolution reaction poses significant challenge. SrIrO3-based perovsk...
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Article
Open AccessWater-stable boroxine structure with dynamic covalent bonds
Boroxines are significant structures in the production of covalent organic frameworks, anion receptors, self-healing materials, and others. However, their utilization in aqueous media is a formidable task due ...
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Article
Open AccessInsights into vehicle conflicts based on traffic flow dynamics
The utilization of traffic conflict indicators is crucial for assessing traffic safety, especially when the crash data is unavailable. To identify traffic conflicts based on traffic flow characteristics across...
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Article
Open AccessThe characteristic analysis of phase-controlled array thermo-acoustic emission with multiple emitting surfaces
Thermo-acoustic (TA) ultrasound, particularly when combined with phased-controlled array technology, has garnered significant interest in the past decade due to its numerous advantages. This paper establishes ...
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Article
Erratum to: Cenozoic giant coal-bearing basin belt discovered in China’s sea area
The original online version of this article was revised: (1) Article title was changed to “Cenozoic giant coal-bearing basin belt discovered in China’s sea and its adjacent areas”; (2) title of Fig. 2 “Coal se...
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Open AccessAnti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer
γδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens, making them attractive candidates for CAR-T-cell therapy. Unlike αβ T cells and other immune cells, γδ T cells are...
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Article
Open AccessUSP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation
Despite its involvement in various cancers, the function of the deubiquitinase USP1 (ubiquitin-specific protease 1) is unexplored in cholangiocarcinoma (CCA). In this study, we provide evidence that USP1 promo...
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Article
Open AccessAssessment of early diabetic retinopathy severity using ultra-widefield Clarus versus conventional five-field and ultra-widefield Optos fundus imaging
To compare early diabetic retinopathy (DR) severity level and the abilities in detecting early DR lesions among conventional five-field, ultrawide-field (UWF) Optos, and UWF Clarus fundus imaging methods. This...
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Article
Open AccessHSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis
Human hydroxysteroid dehydrogenase-like 2 (HSDL2), which regulates cancer progression, is involved in lipid metabolism. However, the role of HSDL2 in cholangiocarcinoma (CCA) and the mechanism by which it regu...
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Article
Open AccessSSDLog: a semi-supervised dual branch model for log anomaly detection
With versatility and complexity of computer systems, warning and errors are inevitable. To effectively monitor system’s status, system logs are critical. To detect anomalies in system logs, deep learning is a ...
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Article
Open AccessProtective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells
Aureobasidium pullulans (A. pullulans) has a wide range of applications. Ultraviolet (UV) rays from the sun can cause skin photoaging. In order to explore the protective effect and application potential of A. pul...
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Article
Open AccessAnti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood–brain-barrier penetration and tumor microenvironment modulation
Inhibition of tumor growth and normalization of immune responses in the tumor microenvironment (TME) are critical issues for improving cancer therapy. However, in the treatment of glioma, effective nanomedicin...
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Article
Open AccessChatGPT for sha** the future of dentistry: the potential of multi-modal large language model
The ChatGPT, a lite and conversational variant of Generative Pretrained Transformer 4 (GPT-4) developed by OpenAI, is one of the milestone Large Language Models (LLMs) with billions of parameters. LLMs have st...
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Open AccessApplication of mesohepatectomy with caudate lobectomy for the treatment of type III–IV hilar cholangiocarcinoma: a single-center retrospective study
The main surgical procedure for Bismuth‒Corlette III–IV hilar cholangiocarcinoma (HCCA) is hemihepatectomy/extended hemihepatectomy. However, many patients have no opportunity for surgery due to having an insu...
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Open AccessCucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging
Organic small-molecule contrast agents have attracted considerable attention in the field of multispectral optoacoustic imaging, but their weak optoacoustic performance resulted from relatively low extinction ...
