5 Result(s)
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Article
Open AccessMesenchymal stem cells enhance CCL8 expression by podocytes in lupus-prone MRL.Faslpr mice
Nephritis is common in systemic lupus erythematosus patients and is associated with hyper-activation of immune and renal cells. Although mesenchymal stem cells (MSCs) ameliorate nephritis by inhibiting T and B...
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Article
Open AccessCHI3L1 induces autophagy through the JNK pathway in lung cancer cells
CHI3L1 is closely related to the molecular mechanisms of cancer cell migration, growth, and death. According to recent research, autophagy regulates tumor growth during various stages of cancer development. Th...
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Open AccessNovel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3
Rheumatoid arthritis (RA) is a severely debilitating chronic autoimmune disease that leads to long-term joint damage. Signal transducer and activator of transcription 3 (STAT3)-targeted small molecules have sh...
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Article
Open AccessPiperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway
Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling pathways. But there has been no study regarding the mechanisms of PL on the lung cancer yet. Thus, we evaluated the a...
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Open AccessFlow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (d-flow), in part, due to alterations in gene expression in the endothelium. While numerous in vitro studies have shown ho...
