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Article
Open AccessBotulinum toxin-A injection into the anterior belly of the digastric muscle for the prevention of post-operative open bite in class II malocclusions: a case report and literature review
Class II malocclusion patients with hyperdivergent facial types are characterized by short mandibular body lengths and anterior open bite. Accordingly, the treatment for hyperdivergent skeletal class II malocc...
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Article
Open AccessCurrent status of the surgery-first approach (part I): concepts and orthodontic protocols
The “surgery-first” approach, defined as a team approach between surgeons and orthodontists for orthognathic surgery without preoperative orthodontic treatment, is aimed at dental decompensation. A brief histo...
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Article
Open AccessAberrant growth of the anterior cranial base relevant to severe midface hypoplasia of Apert syndrome
A 9-year-old male showed severe defects in midface structures, which resulted in maxillary hypoplasia, ocular hypertelorism, relative mandibular prognathism, and syndactyly. He had been diagnosed as having Ape...
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Article
Open AccessEvaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models
Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined t...
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Article
Effect of drug-loaded TiO2 nanotube arrays on osseointegration in an orthodontic miniscrew: an in-vivo pilot study
Osseointegration was evaluated for the surface of miniscrews with TiO2 nanotube arrays containing drugs in this in-vivo study. The diameter and length of the TiO2 nanotube arrays were about 70 nm and 5 μm, respec...
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Article
Open AccessAntitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells
Develo** novel strategies against treatment-resistant triple negative breast cancer (TNBC) cells remains a significant challenge. The ErbB family, including epidermal growth factor receptor (EGFR), plays key...
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Chapter
Breast Cancer Stem Cells
Cancer stem cells (CSCs) represent a heterogeneous subpopulation of cancer cells within tumors. CSCs divide asymmetrically to generate daughter cells that either have CSC characteristics including self-renewal...
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Article
Effect of TiO2 nanotubes arrays on osseointegration of orthodontic miniscrew
To increase the stability of orthodontic miniscrews, TiO2 nanotube arrays were fabricated on the surface of Ti miniscrews and the effect of those arrays on the osseointegration of miniscrews was evaluated. Highly...
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Article
Open AccessInhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with poor survival in patients with breast c...
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Article
Open AccessStudying Cancer Stem Cell Dynamics on PDMS Surfaces for Microfluidics Device Design
This systematic study clarified a few interfacial aspects of cancer cell phenotypes on polydimethylsiloxane (PDMS) substrates and indicated that the cell phenotypic equilibrium greatly responds to cell-to-surf...
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Chapter
Effect of Hepatocyte Growth Factor on the Expression of Matrix Metalloproteinases in the Invasion of Endometrial Cancer Cells in a Three-Dimensional Coculture System
Matrix metalloproteinase (MMP)-2 and -9 are secreted and translocated from endometrial stromal cells to cancer cells in a steroid-dependent manner. We investigated the paracrine effect of hepatocyte growth fac...
