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Open AccessEvaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models
Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined t...
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Article
Open AccessAntitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells
Develo** novel strategies against treatment-resistant triple negative breast cancer (TNBC) cells remains a significant challenge. The ErbB family, including epidermal growth factor receptor (EGFR), plays key...
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Article
Open AccessInhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with poor survival in patients with breast c...
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Effect of Hepatocyte Growth Factor on the Expression of Matrix Metalloproteinases in the Invasion of Endometrial Cancer Cells in a Three-Dimensional Coculture System
Matrix metalloproteinase (MMP)-2 and -9 are secreted and translocated from endometrial stromal cells to cancer cells in a steroid-dependent manner. We investigated the paracrine effect of hepatocyte growth fac...